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Showing 1–6 of 6 results
Advanced filters: Author: Brian Belardi Clear advanced filters
  • Replicating intercellular communication in synthetic cells is challenging. Here, the authors report on engineered connexin nanopores that can be controlled with light to exchange distinct chemical signals between synthetic cells, creating programmable communication networks that mimic cellular interactions.

    • Ahmed Z. Sihorwala
    • Alexander J. Lin
    • Brian Belardi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Numerous proteins interact with the actin cytoskeleton, convoluting their influence on cellular behaviour. Here the authors engineer actin-binding switch tools that can be activated with external stimuli to control the activity of just one protein.

    • Unyime M. Effiong
    • Hannah Khairandish
    • Brian Belardi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology. Here, the authors use a combination of live cell imaging and in vitro single molecule binding measurements to show that tandem calponin homology domains (CH1–CH2) are sensitive to actin filament conformation, biasing their subcellular localization.

    • Andrew R. Harris
    • Pamela Jreij
    • Daniel A. Fletcher
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Dan Fletcher’s lab comments on the unique properties of membranes at cell–cell adhesions, suggesting that cell–cell interfaces are a separate cellular compartment.

    • Brian Belardi
    • Daniel A. Fletcher
    Comments & Opinion
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 747-748
  • Various physiological processes including development and maintenance of epithelia, cell–cell fusion, neuronal function and immune responses rely on the establishment of direct cell–cell contacts. Despite their diversity, the different cell–cell interfaces can be viewed as specialized compartments that perform their distinct functions through common biophysical properties.

    • Brian Belardi
    • Sungmin Son
    • Daniel A. Fletcher
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 750-764