Although high levels of HDL seem to be protective against clinical events from atherosclerosis, assessing the composition and function of HDL is a more-accurate approach to determine cardiovascular risk. The authors of this Review describe the atheroprotective effects of HDL, which have been attributed to its anti-inflammatory properties and role in cholesterol efflux. The relationship between impaired HDL function and cardiovascular disease is also discussed, as well as approaches to evaluate HDL functionality.
- Mohamad Navab
- Srinivasa T. Reddy
- Alan M. Fogelman
