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Triplet excitons generated in a pentacene layer by singlet exciton fission are transferred to lead selenide colloidal nanocrystals with high efficiency when their energy matches the bandgap of the nanocrystals.

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

LYMTACs are heterobifunctional small molecules that take advantage of lysosomal membrane proteins to degrade membrane targets via relocalization and lysosomal degradation, offering a modular approach to drug otherwise intractable membrane proteins.

Colour contrast is added to unstained histological samples by using surface plasmon polaritons whose properties depend on the sample’s dielectric constant.

We introduce a self-assembly strategy that uses the interface of an aqueous two-phase system to template and stabilize molecularly thin biomimetic block copolymer bilayers of scalable area that can exceed 10 cm² without defects.

Human airway contains physiologically relevant yet rare cells, but their scarcity prevents thorough profiling and differentiation studies. Here the authors use single cell RNA sequencing to identify rare ionocytes and tuft cells, as well as a potential progenitor population with cytokine-guided differentiation into either the ionocytes or tuft cell lineage.

Computationally designed genetically encoded proteins can be used to target surface proteins, thereby triggering endocytosis and subsequent intracellular degradation, activating signalling or increasing cellular uptake in specific tissues.

The miniaturization of electronic circuitry requires the reproducible fabrication of electrodes with nanoscale separations. Here, the authors present a robust manufacturing technology that enables programmably placed nanoscale three-dimensional nanogaps on an integrated circuit.

Voltage-modulated scanning probe microscopy may elucidate important processes at solid–liquid interfaces, but it is complicated by the presence of mobile ions. By incorporating force sensitivity into a multidimensional measurement approach, Collins et al.present a technique that overcomes these limitations.

Raising plasmonic nanoantennas on pillars enhances their performance for sensor devices. Here, the authors show that the proximity of such pillar structures can be dynamically tuned by electron beams, offering an additional mechanical degree of freedom to alter their optical properties.

Biomineralization processes have inspired the design of synthetic silica structures in vitro. Here, the authors use a living diatom to fabricate organo-silica constructs and are able to incorporate thiol moieties into the diatom frustule without the loss of nano-scale architectural features.

Highly localized mechanical forces that shape in vivo tissue development remain challenging to recapitulate in vitro. Here the authors use magnetically actuated nanoparticles to generate spatially defined forces within organoids, which guide the spatial organization of tissue patterning and growth.

Biologics are delivered by a pill that pricks the stomach wall.

How fMRI resting-state functional connectivity (rs-FC) in fronto-limbic circuits relates to neural activity is unclear. Here the authors show that rs-FC in these circuits is related to local field potential coherency in the alpha band.

The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology. Here, the authors use a combination of live cell imaging and in vitro single molecule binding measurements to show that tandem calponin homology domains (CH1–CH2) are sensitive to actin filament conformation, biasing their subcellular localization.

Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondrial disease, that Pseudomonas aeruginosa infection prompts innate immune hyperreactivity via interferon-mediated upregulation of caspase11 and guanylate-binding proteins, leading to lung inflammation.

Immune receptors regulate immune responses and are key cancer immunotherapy targets. Here, the authors designed helical concave scaffolds to bind convex sites in immune receptors, creating high-affinity protein binders for TGFβRII, CTLA-4, and PD-L1. Co-crystal structures confirmed their therapeutic potential.

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Gut epithelium generated electrical potentials drive differential localization of enterobacteria, promoting Salmonella tropism for the follicle-associated epithelium while Escherichia coli localize to villi.

The effect of defects on MXene structural transitions in high-temperature environments is shown. Further, defect occupied alkali cations are shown to improve MXenes’ phase stability and control surface diffusion related phase changes.

Large igneous provinces may record pulses mantle plume upwellings and their relationship with deep-rooted mantle sources. Madrigal et al. present a new petrological model of the Pacific Ocean Large Igneous Province finding that mantle plume pulses were separated by 10–20 Ma.

The X-ray crystal structure of the mouse δ-opioid receptor in complex with the subtype-selective antagonist naltrindole is reported.

Zhu and colleagues show that negative-selection ligands induce cooperative TCR–pMHC–CD8 trimolecular ‘catch bonds’, whereas positive-selection ligands induce TCR–pMHC and pMHC–CD8 bimolecular ‘slip bonds’.

The programmability of synthetic cells, comprising lipid vesicles that are capable of imitating the structure and function of living cells, facilitates their application as drug delivery devices. Now, magnetic hyperthermia has been used to control the on-demand synthesis and release of biomolecules from within synthetic cells.

Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.

Here, the authors present photonic resonator interferometric scattering microscopy, which utilises a dielectric photonic crystal as the sample substrate. The resonant near-field enhancement leads to improved signal to noise ratio without increasing illumination intensity.

Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range of human cancers.

The crystal structure of the mouse μ-opioid receptor bound to an antagonist is described, with possible implications for the future development of analgesics.

Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.

An analysis of bowel samples from bowhead whales collected yearly from 2004–2022 indicates increasing algal toxin concentrations in Arctic food webs due to warming ocean conditions.

Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined and the pathophysiology unknown. Here, the authors conduct deep phenotyping of a cohort of PI-ME/CFS patients.

Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.

During transcription, RNA polymerase II (RNAP2) is recruited to promoters and phosphorylated stepwise; so far, these steps have not been visualized in a single-copy gene in live cells. Here the authors use single-molecule microscopy to visualize endogenous phosphorylated RNAP2 and nascent mRNA synthesis at a single locus in living cells.

Sulfated glycosaminoglycans are host cell targets of candidalysin, a cytolytic toxin of the fungal pathogen Candida albicans.

Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin therapy and reduction of cholesterol accumulation in macrophages can ameliorate PAP in both humans and mice.

Autophagy-related proteins ATG16L1, ATG5 and ATG12 are required for plasma membrane repair and help to restrict Listeria monocytogenes toxin-mediated cell-to-cell spread.

Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin modulate cortical signalling through the claustrum, a brain region involved in regulating cognition and brain network states.

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

A wearable array of microneedle-based sensors can be used to wirelessly measure the levels of glucose simultaneously with those of alcohol or lactate in the interstitial fluid of volunteers performing common daily activities.