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Showing 1–6 of 6 results
Advanced filters: Author: Brittney Lozzi Clear advanced filters

  • Astrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10, and this clearance of plaques is associated with the preservation of cognitive function in mouse models.

    • Dong-Joo Choi
    • Sanjana Murali
    • Benjamin Deneen
    Research
    Nature Neuroscience
    Volume: 29, P: 88-99

  • Serotonin has a role in ependymoma tumorigenesis through modifying histones and thereby regulating key transcription factors and activating specific oncogenic transcriptional networks in brain cells.

    • Hsiao-Chi Chen
    • Peihao He
    • Benjamin Deneen
    Research
    Nature
    Volume: 632, P: 903-910

  • Callosal projection neurons located in the hemisphere contralateral to primary glioblastoma promote progression and widespread infiltration, and screening of axon guidance genes identified SEMA4F as a key regulator of tumourigenesis and activity-dependent progression.

    • Emmet Huang-Hobbs
    • Yi-Ting Cheng
    • Benjamin Deneen
    Research
    Nature
    Volume: 619, P: 844-850

  • Long-range enhancer interactions regulate gene expression, yet how they influence CNS development and disease remains unclear. Glasgow et al. identified glia-specific elements and 3D chromatin architectures regulating NFIA expression during development. They also found that deletion of these enhancers suppresses NFIA expression and tumorigenesis in an in vivo glioma model.

    • Stacey M Glasgow
    • Jeffrey C Carlson
    • Benjamin Deneen
    Research
    Nature Neuroscience
    Volume: 20, P: 1520-1528