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Showing 1–4 of 4 results
Advanced filters: Author: Brody Pullinger Clear advanced filters

  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763

  • There are currently no licensed vaccines to prevent Group A Streptococcus (GAS) infections. In this study, the authors evaluate the immune response and preclinical efficacy of a multicomponent mRNA lipid-nanoparticle vaccine against GAS.

    • Nichaela Harbison-Price
    • Ismail Sebina
    • Mark J. Walker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Subgenomic flaviviral RNAs (sfRNAs) are produced by pathogenic flaviviruses to counteract the host antiviral response. sfRNAs are products of incomplete degradation of viral RNA by the host exoribonuclease XRN1 which stalls on XRN1-resistant structural elements (xrRNAs) in the 3‟UTR. Here, Slonchak et al. identify xrRNAs for mosquito-specific flaviviruses, characterize their ability to stall XRN1 and produce sfRNAs, and apply structure-based phylogenetic analysis to provide evidence for evolutionary selection of these elements.

    • Andrii Slonchak
    • Rhys Parry
    • Alexander A. Khromykh
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

    • Carolina Roselli
    • Mark D. Chaffin
    • Patrick T. Ellinor
    Research
    Nature Genetics
    Volume: 50, P: 1225-1233