Nature Search

Experimentally profiling dielectric properties of Escherichia coli and Staphylococcus aureus by movement velocity and force

Akmal Suhaimi
Arash Zulkarnain
Ramdzan Buyong
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Crystal structure of a plectonemic RNA supercoil

Nucleic acid superstructures are required to package genomes into the nucleus of cells. In this study, the superstructure of an RNA supercoil species is reported and is shown to be dependent on an RNA-binding protein that induces a higher level of organization compared with DNA superstructures.

Jason R. Stagno
Buyong Ma
Xinhua Ji
Research12 Jun 2012
Nature Communications

Volume: 3, P: 1-5
Visualizing RNA conformational and architectural heterogeneity in solution

RNA conformational heterogeneity is important to diverse functions. Here, the authors use AFM to directly visualize individual RNA molecules that are in various conformational states under near physiological solution conditions for the first time.

Jienyu Ding
Yun-Tzai Lee
Yun-Xing Wang
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-11
Conformational footprints

The mechanisms by which proteins evolve new functions can be slow and mysterious. Comprehensive structural analysis of enzyme variants reveal how gradual enrichments of pre-existing populations with the right productive dynamics for new functions can accomplish this aim.

Buyong Ma
Ruth Nussinov
News & Views18 Oct 2016
Nature Chemical Biology

Volume: 12, P: 890-891
How do transcription factors select specific binding sites in the genome?

How does a transcription factor select a specific DNA response element given the presence of degenerate sequences? To date, this question has largely been viewed from the standpoint of DNA sequence variability and transcription factor binding affinity under steady-state conditions. Here we propose that to address this problem, it is also necessary to account for fluctuating cellular conditions. These lead to dynamic changes in the ensemble of protein (and DNA) conformational states via allosteric effects.

Yongping Pan
Chung-Jung Tsai
Ruth Nussinov
Comments & Opinion01 Nov 2009
Nature Structural & Molecular Biology

Volume: 16, P: 1118-1120
Randomized double-blind crossover trial of a transdermal maltose dissolvable microneedle patch for topical anesthesia before intravenous cannulation for thalassemia children

Muhammad Irfan Abdul Jalal
Kai Shen Ooi
Fook Choe Cheah
ResearchOpen Access29 Nov 2025
Scientific Reports

Volume: 16, P: 1-13
Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

Aβ(1–42) is the most pathogenic amyloid-β species in Alzheimer's disease (AD). The solid-state NMR–based atomic model of an Aβ(1–42) fibril elucidates the mechanism of fibril formation and propagation in AD and other amyloid diseases.

Yiling Xiao
Buyong Ma
Yoshitaka Ishii
Research04 May 2015
Nature Structural & Molecular Biology

Volume: 22, P: 499-505
Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells

Structural-, biophysical- and imaging data show that self-assembly of the pericentrosomal proteins Cep63 and Cep152 is a stepwise and concentration-dependent process and that a defect in this event disrupts proper Plk4-mediated centriole duplication

Jong Il Ahn
Liang Zhang
Kyung S. Lee
ResearchOpen Access11 Jul 2023
Communications Biology

Volume: 6, P: 1-20
Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane

Mingzhen Zhang
Jie Zheng
Buyong Ma
ResearchOpen Access01 Jun 2017
Scientific Reports

Volume: 7, P: 1-13
Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane

Mingzhen Zhang
Jie Zheng
Buyong Ma
ResearchOpen Access15 Sept 2016
Scientific Reports

Volume: 6, P: 1-13
Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells

Jong Il Ahn
Liang Zhang
Kyung S. Lee
Amendments and CorrectionsOpen Access27 Jul 2023
Communications Biology

Volume: 6, P: 1-4

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Experimentally profiling dielectric properties of Escherichia coli and Staphylococcus aureus by movement velocity and force

Crystal structure of a plectonemic RNA supercoil

Visualizing RNA conformational and architectural heterogeneity in solution

Conformational footprints

How do transcription factors select specific binding sites in the genome?

Randomized double-blind crossover trial of a transdermal maltose dissolvable microneedle patch for topical anesthesia before intravenous cannulation for thalassemia children

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells

Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane

Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane

Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells

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