Cognitive deficits are long-lasting consequences of drug use, yet the convergent mechanism by which classes of drugs with different pharmacological properties cause similar deficits is unclear. Here authors show that phencyclidine and methamphetamine both cause glutamatergic neurons in the medial prefrontal cortex to gain a GABAergic phenotype and decrease expression of their glutamatergic phenotype, and further that suppression of drug-induced gain of GABA prevents memory deficits.
- Marta Pratelli
- Anna M. Hakimi
- Nicholas C. Spitzer
