Here the authors analyse genetic data for over 400,000 British and Irish people, showing that the frequency of the major genetic risk factor for haemochromatosis varies from a low of 1/212 in Southern England to 1/62-1/54 in Outer Hebrideans and Northwest Irish. Clinically diagnosed haemochromatosis varies 11- fold in frequency across England, emphasising the uneven risk landscape.
- Shona M. Kerr
- Benjamin S. Fletcher
- James F. Wilson