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A photonic-crystal platform enables attojoule-energy electro-optic modulators and amplifier-free photoreceivers.

Synthetic dimensions can introduce band properties without a periodic structure in real space, but they have largely been studied in linear systems. A study using an optical resonator has now shown non-linear soliton states in synthetic frequency space.

Glycogen metabolism is tightly regulated. Here the authors describe the 3D structure of the PP1/PTG protein complex, which plays a prominent role in the activation of glycogen synthesis and in the pathogenesis of Lafora disease, the most severe form of pediatric progressive epilepsy.

Graphene exhibits interesting optical and electronic properties, resulting from a Dirac dispersion of electrons. Shimano et al.observe quantum magneto-optical Faraday and Kerr effects in the terahertz regime, where plateaus are observed at the quantum-Hall steps.

Neuropeptides are potent feeding modulators, but how these endogenous signals shape relevant neurocircuits remains unclear. Here, the authors show that hypothalamic neuropeptide Y drives input-specific synaptic plasticity, enabling a selective shift in hunger and anxiety signaling during starvation.

Skeletal muscle satellite cells are muscle stem cells believed to contribute only to regenerating myofibres. Here Keefe et al. show that in adult sedentary mice satellite cells continue to fuse with uninjured myofibres, but they are not globally required for the maintenance of aging muscles.

Due to three-dimensional, stochastic and non-repeatable transitions of dissipative solitons, it is challenging to monitor their full dynamics. Here, the authors resolve the dynamics by wavelength and along two spatial dimensions with up to trillions of frames per second using compressed ultrafast photography.

Current applications of NV centers in diamond as spin-photon interfaces for quantum networks are limited by low coherent photon emission. Here, the authors integrate a coherently controlled NV spin qubit with an open microcavity to achieve Purcell-enhanced emission and demonstrate spin-photon state generation.

By exploiting the long-lived phonon modes in nanoscale mechanical resonators, a quantum memory that operates around the standard telecom wavelength of 1,550 nm is realized on a silicon platform.

Operating macroscopic mechanical resonators in the quantum regime has recently attracted significant interest. Here, the authors demonstrate ground-state cooling of a nanostring mechanical resonator via measurement-based feedback, reaching 0.76 average phonon occupation starting from liquid helium temperature, and 3.5 when starting from liquid nitrogen.

Future quantum technologies will require interfaces between photons transmitting information and solid-state devices storing and manipulating it. Towards this aim, Gao et al.show the transfer of information from a single photon to a semiconductor quantum dot through quantum teleportation protocols.

Integrated photodetectors are essential for scalable photonic platforms, yet most efforts are concerted on the developing devices operating at infrared telecommunication wavelengths. Here, the authors report a monolithically integrated avalanche photodetector for visible light based on doped-Si rib waveguide with end-fire input coupling to a silicon nitride waveguide.

Adding tunable photon-photon nonlinearities to programmable photonic circuits would greatly extend their capabilities. Here, the authors demonstrate this by embedding a photonic-crystal waveguide nanostructure hosting an InAs quantum dot within a programmable linear optical circuit, and using it to realise a proof-of-concept quantum simulation of anharmonic molecular vibrational dynamics.

Authors describe the distinct modulation by spermine on the Alzheimer’s Tau and Parkinson’s α-synuclein proteins, elucidating their protein condensation behaviors both in vitro and in vivo.

Birefringent particles manipulated with an optical torque wrench exhibit strongly nonlinear, ‘excitable’ behaviour similar to that governing the firing of neurons. This technique could be used to detect small perturbations in the local environment of such a particle.

A lithium niobate nonlocal metasurface with high-Q (~8000) resonances demonstrates efficient GHz-rate reflectivity modulation (~0.1) and one order of magnitude second harmonic modulation using sub-10V driving voltages, offering promising applications in high-speed nanophotonics.

Nano-mechanical resonators improve with high-Q factor and light mass, but this leads to the onset of nonlinear behaviour. Here the authors demonstrate precise control of the non-linear and bistable dynamics of a levitated nanoparticle in vacuum, using it as model system to study stochastic bistable phenomena.

The photophysics of thymine in the gas phase are still under debate. Here the authors perform coupled-cluster-based dynamics simulations to predict time-resolved X-ray absorption spectra and reveal a hydrogen dissociation channel.

By exploiting the interaction between light and phonons in a silica microsphere resonator it is possible to generate Brillouin scattering induced transparency, which is akin to electromagnetically induced transparency but for acoustic waves.

Entanglement of two nanophotonic quantum network nodes is demonstrated through 40  km spools of low-loss fibre and a 35-km long fibre loop deployed in the Boston area urban environment.

Quantum teleportation of a photonic qubit into mechanical modes of two silicon photonic crystal nanobeams is demonstrated. It allows to store and retrieve an arbitrary qubit state onto a dual-rail encoded long-lived optomechanical quantum memory.

A protocol to recover states of optical continuous-variable entanglement is developed based on approximate heralded noiseless amplification. The degraded entanglement is completely recovered no matter how significant these losses are.

Controllable non-reciprocal hopping is crucial for emerging photonic technologies. Here, the authors demonstrate a tunable microwave system exhibiting non-Hermitian, phase-non-reciprocal, and nonlinear dynamics, with potential relevance to sensing, quantum networks, and synthetic photonic materials.

Sam68 and T-STAR are members of the STAR family of proteins, which regulate various aspects of RNA metabolism. Here, the authors reveal structural features required for alternative splicing regulation by these proteins.

Trapped ions are promising for electrometry but limited by their weak intrinsic spin coupling to electric fields. Now it is shown that using a magnetic field gradient enhances sensitivity and enables precise measurements across subhertz to kilohertz frequencies.

Interference of linear plane waves produces non-trivial phenomena in both classical and quantum wave systems. Here, the authors describe and observe anomalously large time delays and frequency shifts in the resonant inelastic scattering of a 1D wave packet near a zero of the scattering coefficient.

Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.

By implanting ¹¹⁷Sn, a fibre-packaged nanophotonic diamond waveguide with optically addressable hyperfine transitions separated by 452 MHz is demonstrated. This enables the formation of a spin-gated optical switch and achieving a waveguide-to-fibre extraction efficiency of 57%.

X-ray ultrafast transient absorption spectroscopy captures the charge migration in neutral silane molecules, which shows in the spectra as pairs of quantum beats.

Magic numbers are associated with the stability of atomic nuclei. Here, the authors analyse the proton radii, binding energies and electric quadrupole transition rates of neutron-rich carbon isotopes at proton number six and use nuclear structure models to support the magic number Z = 6.

Proapoptotic signals trigger the transition of cIAP1 from an autoinhibited monomeric form to an activated dimer. NMR and time-resolved SAXS analyses reveal the conformational dynamics of the cIAP1 monomer that facilitates rapid and irreversible activation.

Antibiotic resistance is a major clinical problem that threatens to undermine our ability to control infectious diseases. Here the authors present detailed structural analysis of Rifampin phosphotransferase from Listeria monocytogenes, yielding insight on how this class of enzyme inactivates its target antibiotics.

Crystal structure analysis of the Phd transcription factor bound to the DNA operator combined with biophysical studies reveal an interplay between intrinsically disordered regions and conditional cooperativity for operon binding and repression.

Designing computational methods that can accurately predict useful material properties is an attractive alternative to cumbersome trial and error experimental approaches. Here, the authors present a computational method based on neural-network quantum states, which can reveal many-body quantum phenomena of a solid state system similar to first-principles calculations.

The authors investigate the X-ray-induced electron dynamics, on the sub-femtosecond timescale, of hydrated Na⁺, Mg²⁺, and Al³⁺ ions providing insights into the ultrafast charge-transfer processes in aqueous environments.

Generating photonic cluster states using a single non-heralded source and a single entangling gate would optimise scalability and reduce resource overhead. Here, the authors generate up to 4-photon cluster states using a quantum dot coupled to a fibre loop, with a fourfold generation rate of 10 Hz.

Entanglement is not the only type of quantum correlation. Quantum discord is a broader measure of such non-classical interactions. An experimental investigation now shows how quantum discord can be consumed to encode information, even in the absence of entanglement.

Crystal structures, along with biochemistry data, capture the active form of the Dcp2 decapping enzyme in complex with Dcp1 and a peptide from Edc1, thus revealing the mechanism of activation by Dcp1 and Edc1 activators.

Efficient memory systems are vital for the development of quantum communications technologies. Hosseini and colleagues describe an optical memory based on warm rubidium vapour that achieves 87% pulse recall efficiency, illustrating the potential of warm atomic vapour systems for quantum memory.

Design and fabrication techniques that allow analogous dispersion control in chip-integrated optical microresonators are presented, allowing higher-order, wide-bandwidth dispersion control over an octave of spectrum.

A modular quantum system-on-chip architecture integrates thousands of individually addressable spin qubits in two-dimensional quantum microchiplet arrays into an integrated circuit designed for cryogenic control, supporting full connectivity for quantum memory arrays across spin–photon channels.

IgE is linked to allergic diseases and there is a great interest in developing anti-IgE therapeutics. Here the authors characterize the binding of human IgE Fc to a single domain antibody (sdab) and show that the sdab induces a closed conformation, which prevents and disrupts IgE binding to its receptor FcεRI and abrogates allergen mediated activation.