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Li et al. perform a phase 2 single-arm clinical trial of neoadjuvant chemotherapy plus checkpoint blockade in participants with resectable muscle-invasive bladder cancer and conduct genomic and transcriptomic profiling to describe molecular subtypes.

Using a field experiment, this study shows that both lowland and alpine plant species experience greater competitive effects and a reduced ability to coexist towards their elevation range edges due to increased niche overlap and competitive inequality. These findings suggest competition helps set both lower and upper elevation range limits.

This study suggests a mechanism by which LSD1 controls DNA methylation in mouse ESCs, independently of its lysine demethylase activity. The demethylase-independent function of LSD1 regulates the DNMT1 and UHRF1 protein stability through interaction with USP7 and HDAC1.

The volatilization of alkaline ions is a main factor to degrade the performances of KNN films. Here, the authors utilized the volatilization and incorporation of Mn to construct periodical Mn-inlaid antiphase boundaries in KNN matrix, leading to an improvement of ferroelectric properties.

Crystal structures of the σ₂ receptor are determined and used to perform a docking screen of nearly 500 million molecules, identifying σ₂-selective ligands and providing insight into the role of σ₂ in neuropathic pain.

Understanding charge-compensating interactions and ionic dynamics in organic mixed conductors can be challenging. Operando NMR spectroscopy is now used to quantify cation and water movement during doping/dedoping in mixed conductor films.

Faecal metagenomics and serum metabolomics reveal compositional and functional alterations in the gut microbiota of women with anorexia nervosa, and faecal transplants could transfer an anorexia-associated phenotype to germ-free mice.

Copper level fluctuations are shown to modulate EGFR signal transduction via inhibition of the phosphatase PTPN2, culminating in CREB transcription factor activity, which is associated with transcriptional repression of the copper importer CTR1.

Colorectal cancer is discriminated by measuring cell-free RNA methylation in plasma.

Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Here the authors show that elevated expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), the enzyme driving local bone GC activation, is associated with bone loss and obesity mice.

A newly identified exercise-induced signalling metabolite—an amidated conjugate of lactate and phenylalanine—can reduce food intake and improve blood glucose homeostasis.

Extracellular vesicles are reported to regulate tumorigenesis. Here, the authors show that under obesity conditions, increased extracellular matrix protein 1 protein levels in circulating small extracellular vesicles induce breast cancer growth and metastasis.

This study maps global tree composition in forests and assesses the impacts of historical forest cover loss and climate change. The results highlight the need for preserving the remaining large forest biomes, while regenerating degraded forests in a way that provides resilience against climate change.

How plant height is adaptive to high latitudes and high density planting is unclear. Here, the authors report a retrotransposon insertion in a WD40 protein encoding gene PH13 affects its interaction with GmCOP1s and increases the abundance of STF1/2, leading to reduced soybean height and increased shade resistance.

A ceramic-based metal–organic framework can be used to realize nanoporous membranes with improved stability over polymeric membranes.

In order to explore superconductivity in hydride materials, local magnetometry inside a diamond anvil cell is performed with sub-micron spatial resolution at megabar pressures using nitrogen-vacancy colour centres.

A high-quality reference genome assembly of cauliflower C-8 (V2) and genomic analyses of 971 diverse accessions and their relatives reveal the stepwise domestication and the genetic mechanism of curd biogenesis.

Solid-state systems are established candidates to study models of many-body physics but have limited control and readout capabilities. Ensembles of defects in diamond may provide a solution for studying dipolar systems.

Atmospheric short-wave absorption due to wildfire smoke is caused predominantly by dark brown carbon particles, according to observations from smoke plumes in the United States.

Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.

During replication stress, the RPA protein complex coats single-stranded DNA to preclude RAD51 loading. Here, the authors show how RPA and CST crosstalk to regulate RAD51 activity.

Toroidic phases and their phase transitions are notoriously hard to study in natural materials. Now, a direct-kagome spin ice provides access to two low-temperature toroidal phases, ferrotoroidicity and paratoroidicity, as well as to toroidic phase transitions.

Serotonin is implicated in mood-related disorders, yet direct evidence linking it to disease precipitation or treatment remains limited. Here, authors show that histone serotonylation contributes to stress- and antidepressant-mediated phenotypes, which may be of clinical relevance.

A machine-learning algorithm based on an array of demographic, physiological and clinical information is able to predict, hours in advance, circulatory failure of patients in the intensive-care unit.

Strong near-infrared spectral features from asymptotic giant branch stars are detected by JWST in the integrated light from distant quiescent galaxies, clarifying their contribution to galaxy spectra and population synthesis models.

A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

Most functional genomic resources have been based on individuals with European ancestry. Here, the authors perform DNA methylation quantitative trait locus (mQTL) analyses in 3,701 European and 2,099 East Asian individuals to identify thousands of genetic variants, a large degree of which are shared between the two populations.

Extensive genomic analyses of the chromatin architecture in acute myeloid leukaemia reveals several characteristics, including subtype-specific distal enhancers and silencers, that may represent new anticancer therapeutic targets.

Removing immunogenic uncapped mRNA from transcribed mRNA can be challenging, but is critical in mRNA research and clinical applications such as vaccines. Here, authors develop hydrophobic photocaged tag-modified cap analogs, which can be used to separate capped mRNA from uncapped mRNA, with subsequent tag removal using photo-irradiation.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

Metabolic rewiring during tachycardia promotes tissue hypoxia, elevated glucose utilization and the suppression of oxidative phosphorylation, driving contractile dysfunction.

Auxin is a key regulator in vascular cambium development. This study shows that gibberellins promote polar auxin transport along the root, which leads to broadening of high auxin signalling domain in cambium, and thus, to increased xylem formation.

Health-oriented emissions reduction in China focusing on the iron and steel industry can reduce costs by 1.56 billion dollars while lowering the population-weighted toxic potency-adjusted exposure risk.

Light-induced artificial goosebumps on liquid crystal elastomer skin are used to precisely manipulate passive microstructures, achieving a localized and controllable system for programmable micromachines.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

Extreme myopia (EM) is a leading cause of sight impairment caused by progressive retinal degeneration. Here, the authors perform whole-exome sequencing to investigate rare protein-truncating variants among EM cases and identify KDELR3 which contributes to the pathogenesis of EM.

Previous studies on the connection between food environments and cardiometabolic diseases have yielded inconclusive results. Here, the authors show that integrating human activity into assessments of food environments can better predict the prevalence of cardiometabolic diseases.

The synthesis of interlocking molecular [n]catenanes of organic polyhedra (n = 2–3) and rings (n = 2–130) is established; however, the analogous chemistry of infinite 3D structures remains undeveloped. Now, reticular chemistry enables the synthesis of crystalline [∞]catenane covalent organic frameworks constructed from interlocking organic polyhedra.

The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.

Reproduction incurs a physiological cost as a result of evolutionary fitness optimization. In male Drosophila, key reproductive costs are shown to be a result of perceiving female pheromones, and the act of mating reverses the costs.