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Showing 1–24 of 24 results
Advanced filters: Author: C. Robin Buell Clear advanced filters
  • A combination of isotopic labelling, gene silencing, single-nucleus RNA sequencing and comparative transcriptomics reveal the genes that mediate the biosynthesis of cinchona alkaloids in plants.

    • Blaise Kimbadi Lombe
    • Tingan Zhou
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature
    P: 1-9
  • Potato is clonally propagated, with a complex genome and a challenging breeding system. Genome-enabled approaches have shed light on the molecular genetic basis of key traits, thereby enabling accelerated breeding strategies and bringing potato in line with other key food crops such as maize and rice that exploit heterosis.

    • C. Robin Buell
    News & Views
    Nature Plants
    Volume: 12, P: 490-491
  • Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (kratom) and study their inclusion in downstream biosynthesis.

    • Allwin McDonald
    • Yoko Nakamura
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 22, P: 229-238
  • Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

    • Dmitry A. Abanin
    • Rajeev Acharya
    • Nicholas Zobrist
    ResearchOpen Access
    Nature
    Volume: 646, P: 825-830
  • Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.

    • Maite Colinas
    • Chloée Tymen
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Plants
    Volume: 11, P: 2204-2216
  • The medicinal plant Catharanthus roseus is a source of leading anticancer drugs. The monoterpene indole alkaloid (MIA) biosynthetic pathway in C. roseus has now been analyzed using a complementary, multi-omics, single-cell approach. This identified clusters of genes involved in MIA biosynthesis and cell-type-specific partitioning in the MIA biosynthetic pathway.

    • Chenxin Li
    • Joshua C. Wood
    • C. Robin Buell
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 1031-1041
  • In contrast to common bean, tepary bean is highly adapted to heat and drought. Here, the authors assemble the genomes of tepary bean landrace and wild accession, discuss the possible mechanism for resilience to heat stress, and reveal a reduced disease resistance gene repertoire.

    • Samira Mafi Moghaddam
    • Atena Oladzad
    • Phillip E. McClean
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • A diterpenoid biosynthetic gene cluster (BGC) has been identified in a few species in the Lamiaceae (mint) family, but its origin and evolution remain unclear. Here, the authors report assembly of genomes of three species within the family and reveal the dynamic evolutionary trajectory of the BGC.

    • Abigail E. Bryson
    • Emily R. Lanier
    • Björn Hamberger
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone stereoisomers, as a versatile system for the production of the iridoid natural product scaffold.

    • Néstor J. Hernández Lozada
    • Benke Hong
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • Sweetpotato is an important food security crop providing rich source of macro- and micronutrients including carbohydrates and vitamins. Here, the authors assemble of the two diploid relatives of cultivated sweetpotato and identify genes and alleles associated with carotenoid biosynthesis from breeding lines.

    • Shan Wu
    • Kin H. Lau
    • Zhangjun Fei
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • Remarkable organ shape morphological diversity exists in fruits, vegetables and seeds. Here, the authors establish a link between OVATE Family Proteins and TONNEAU1 Recruiting Motif family proteins in the development pathway that governs fruit shape of tomato, melon, and cucumber as well as potato tuber shape.

    • Shan Wu
    • Biyao Zhang
    • Esther van der Knaap
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • High-quality diploid assemblies of potato genomes from 24 wild and 20 cultivated potatoes provide insights into the complex evolution and diversity of potatoes, and could have applications in the breeding of hybrid potatoes.

    • Dié Tang
    • Yuxin Jia
    • Sanwen Huang
    ResearchOpen Access
    Nature
    Volume: 606, P: 535-541
  • The millimetre image of the Centaurus A nucleus by the Event Horizon Telescope reveals a highly collimated, asymmetrically edge-brightened jet. The source’s event horizon shadow should be visible at terahertz frequencies, consistent with the universal scale invariance of black holes.

    • Michael Janssen
    • Heino Falcke
    • Shan-Shan Zhao
    ResearchOpen Access
    Nature Astronomy
    Volume: 5, P: 1017-1028
  • Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

    • Rajeev Acharya
    • Dmitry A. Abanin
    • Nicholas Zobrist
    ResearchOpen Access
    Nature
    Volume: 638, P: 920-926
  • Haplotype-resolved assembly of a heterozygous diploid potato, RH89-039-16, and identification of deleterious mutations provide insights into the genome organization and breeding of a clonally propagated diploid species.

    • Qian Zhou
    • Dié Tang
    • Sanwen Huang
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 1018-1023