Nature Search

Enzymatic epimerization of monoterpene indole alkaloids in kratom

Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (kratom) and study their inclusion in downstream biosynthesis.

Allwin McDonald
Yoko Nakamura
Sarah E. O’Connor
ResearchOpen Access16 Jul 2025
Nature Chemical Biology

Volume: 22, P: 229-238
Observation of constructive interference at the edge of quantum ergodicity

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Dmitry A. Abanin
Rajeev Acharya
Nicholas Zobrist
ResearchOpen Access22 Oct 2025
Nature

Volume: 646, P: 825-830
Discovery of iridoid cyclase completes the iridoid pathway in asterids

Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.

Maite Colinas
Chloée Tymen
Sarah E. O’Connor
ResearchOpen Access03 Oct 2025
Nature Plants

Volume: 11, P: 2204-2216
Single-cell multi-omics in the medicinal plant Catharanthus roseus

The medicinal plant Catharanthus roseus is a source of leading anticancer drugs. The monoterpene indole alkaloid (MIA) biosynthetic pathway in C. roseus has now been analyzed using a complementary, multi-omics, single-cell approach. This identified clusters of genes involved in MIA biosynthesis and cell-type-specific partitioning in the MIA biosynthetic pathway.

Chenxin Li
Joshua C. Wood
C. Robin Buell
ResearchOpen Access15 May 2023
Nature Chemical Biology

Volume: 19, P: 1031-1041
The tepary bean genome provides insight into evolution and domestication under heat stress

In contrast to common bean, tepary bean is highly adapted to heat and drought. Here, the authors assemble the genomes of tepary bean landrace and wild accession, discuss the possible mechanism for resilience to heat stress, and reveal a reduced disease resistance gene repertoire.

Samira Mafi Moghaddam
Atena Oladzad
Phillip E. McClean
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-14
Phased chromosome-level assembly provides insight into the genome architecture of hexaploid sweetpotato

This study developed a phased chromosome-level genome assembly for the African sweetpotato cultivar ‘Tanzania’, revealing the complex genome architecture of hexaploid sweetpotato and providing valuable insights into its origin.

Shan Wu
Honghe Sun
Zhangjun Fei
Research08 Aug 2025
Nature Plants

Volume: 11, P: 1951-1959
Author Correction: Biocatalytic routes to stereo-divergent iridoids

Néstor J. Hernández Lozada
Benke Hong
Sarah E. O’Connor
Amendments and CorrectionsOpen Access27 Sept 2022
Nature Communications

Volume: 13, P: 1
Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

A diterpenoid biosynthetic gene cluster (BGC) has been identified in a few species in the Lamiaceae (mint) family, but its origin and evolution remain unclear. Here, the authors report assembly of genomes of three species within the family and reveal the dynamic evolutionary trajectory of the BGC.

Abigail E. Bryson
Emily R. Lanier
Björn Hamberger
ResearchOpen Access20 Jan 2023
Nature Communications

Volume: 14, P: 1-14
Biocatalytic routes to stereo-divergent iridoids

Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone stereoisomers, as a versatile system for the production of the iridoid natural product scaffold.

Néstor J. Hernández Lozada
Benke Hong
Sarah E. O’Connor
ResearchOpen Access11 Aug 2022
Nature Communications

Volume: 13, P: 1-13
Genome sequences of two diploid wild relatives of cultivated sweetpotato reveal targets for genetic improvement

Sweetpotato is an important food security crop providing rich source of macro- and micronutrients including carbohydrates and vitamins. Here, the authors assemble of the two diploid relatives of cultivated sweetpotato and identify genes and alleles associated with carotenoid biosynthesis from breeding lines.

Shan Wu
Kin H. Lau
Zhangjun Fei
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-12
A common genetic mechanism underlies morphological diversity in fruits and other plant organs

Remarkable organ shape morphological diversity exists in fruits, vegetables and seeds. Here, the authors establish a link between OVATE Family Proteins and TONNEAU1 Recruiting Motif family proteins in the development pathway that governs fruit shape of tomato, melon, and cucumber as well as potato tuber shape.

Shan Wu
Biyao Zhang
Esther van der Knaap
ResearchOpen Access09 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Simulated deep space exposure on seeds utilizing the MISSE flight facility

Jeffrey T. Richards
Todd E. Mortenson
Ye Zhang
ResearchOpen Access17 Jan 2025
npj Microgravity

Volume: 11, P: 1-11
Genome evolution and diversity of wild and cultivated potatoes

High-quality diploid assemblies of potato genomes from 24 wild and 20 cultivated potatoes provide insights into the complex evolution and diversity of potatoes, and could have applications in the breeding of hybrid potatoes.

Dié Tang
Yuxin Jia
Sanwen Huang
ResearchOpen Access08 Jun 2022
Nature

Volume: 606, P: 535-541
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

Xiaoying Lin
Samir Kaul
J. Craig Venter
Research16 Dec 1999
Nature

Volume: 402, P: 761-768
Sequencing of a rice centromere uncovers active genes

Kiyotaka Nagaki
Zhukuan Cheng
Jiming Jiang
Research11 Jan 2004
Nature Genetics

Volume: 36, P: 138-145
Event Horizon Telescope observations of the jet launching and collimation in Centaurus A

The millimetre image of the Centaurus A nucleus by the Event Horizon Telescope reveals a highly collimated, asymmetrically edge-brightened jet. The source’s event horizon shadow should be visible at terahertz frequencies, consistent with the universal scale invariance of black holes.

Michael Janssen
Heino Falcke
Shan-Shan Zhao
ResearchOpen Access19 Jul 2021
Nature Astronomy

Volume: 5, P: 1017-1028
Quantum error correction below the surface code threshold

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Rajeev Acharya
Dmitry A. Abanin
Nicholas Zobrist
ResearchOpen Access09 Dec 2024
Nature

Volume: 638, P: 920-926
Genome sequence and analysis of the tuber crop potato

Xun Xu
Shengkai Pan
Richard G. F. Visser
ResearchOpen Access10 Jul 2011
Nature

Volume: 475, P: 189-195
Addendum: Genome evolution and diversity of wild and cultivated potatoes

Dié Tang
Yuxin Jia
Sanwen Huang
Amendments and CorrectionsOpen Access13 Sept 2022
Nature

Volume: 609, P: E14
Haplotype-resolved genome analyses of a heterozygous diploid potato

Haplotype-resolved assembly of a heterozygous diploid potato, RH89-039-16, and identification of deleterious mutations provide insights into the genome organization and breeding of a clonally propagated diploid species.

Qian Zhou
Dié Tang
Sanwen Huang
ResearchOpen Access28 Sept 2020
Nature Genetics

Volume: 52, P: 1018-1023
Elevating the conversation about GE crops

Fred Gould
Richard M Amasino
Robert J Whitaker
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 302-304
Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family

Zahra Aminfar
Babak Rabiei
Mohammad Hossein Mirjalili
ResearchOpen Access01 Nov 2019
Scientific Reports

Volume: 9, P: 1-15

Search

Enzymatic epimerization of monoterpene indole alkaloids in kratom

Observation of constructive interference at the edge of quantum ergodicity

Discovery of iridoid cyclase completes the iridoid pathway in asterids

Single-cell multi-omics in the medicinal plant Catharanthus roseus

The tepary bean genome provides insight into evolution and domestication under heat stress

Phased chromosome-level assembly provides insight into the genome architecture of hexaploid sweetpotato

Author Correction: Biocatalytic routes to stereo-divergent iridoids

Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

Biocatalytic routes to stereo-divergent iridoids

Genome sequences of two diploid wild relatives of cultivated sweetpotato reveal targets for genetic improvement

A common genetic mechanism underlies morphological diversity in fruits and other plant organs

Simulated deep space exposure on seeds utilizing the MISSE flight facility

Genome evolution and diversity of wild and cultivated potatoes

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

Sequencing of a rice centromere uncovers active genes

Event Horizon Telescope observations of the jet launching and collimation in Centaurus A

Quantum error correction below the surface code threshold

Genome sequence and analysis of the tuber crop potato

Addendum: Genome evolution and diversity of wild and cultivated potatoes

Haplotype-resolved genome analyses of a heterozygous diploid potato

Elevating the conversation about GE crops

Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family

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