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Showing 1–4 of 4 results
Advanced filters: Author: Caitlyn L. Holmes Clear advanced filters

  • Tracing barcoded clones of Klebsiella pneumoniae during pneumonia with bacteremia, Holmes and colleagues identify two modes of dissemination, with high or low bacterial burdens, and define the host and bacterial factors that influence this process.

    • Caitlyn L. Holmes
    • Katherine G. Dailey
    • Michael A. Bachman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Ryan et al. report a highly conserved mechanism by which arginine induces changes in hypervirulent Klebsiella pneumoniae bacterial cell surface capsule. K. pneumoniae arginine sensing is critical for full virulence potential.

    • Brooke E. Ryan
    • Caitlyn L. Holmes
    • Laura A. Mike
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Patient variables, such as comorbidities, partially explain which patients will progress to Klebsiella infection, with colonization of the gut acting as a reservoir. Little is known, however, regarding Klebsiella genes that may increase risk of disease in colonized individuals. Here, authors conduct a comparative genomics study to identify genes associated with progression from colonisation to infection.

    • Jay Vornhagen
    • Emily K. Roberts
    • Michael A. Bachman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • In this Review, Holmes, Bachman and colleagues explore the prevalence of the major pathogens causing bloodstream infections, prominent mechanisms of bloodstream infection pathogenesis, opportunities for prevention and diagnosis, and treatment options.

    • Caitlyn L. Holmes
    • Owen R. Albin
    • Michael A. Bachman
    Reviews
    Nature Reviews Microbiology
    Volume: 23, P: 210-224