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“Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”

Spin-current-induced magnetization reversal of a perpendicularly magnetized thulium iron garnet film is reported. The spin current is driven by the current flowing through a Pt overlayer.

Single-atom catalysts can exhibit improved catalytic performance with respect to their bulk counterparts. Now, the authors introduce a yolk@shell catalyst with spatially separated Pd and Fe single sites that simultaneously catalyse nitroaromatic hydrogenation and alkene epoxidation reactions, leading to a cascade synthesis of amino alcohols.

A Li⁺-assisted liquid-phase reduction method is reported, which converts crystalline metal oxides into amorphous metal oxides. The electrostatic interaction between the naphthalene radical anions and Li⁺-inserted metal oxides is found to promote the amorphization process.

Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather pathological information for timely interventions. Here, the authors introduce a biodegradable and restorative neural interface for wireless real-time tracking.

Spin–orbit torques in heavy metal/ferromagnetic layers have a complex dependence on the magnetization direction. This dependence can be exploited to increase the efficiency of spin–orbit torques.

Potential anti-tumor therapies remain to be discovered in cancer cell line high-throughput screening datasets. Here, the authors develop a machine learning approach to infer cancer cell drug sensitivity from transcriptomics data and to explore drug mechanisms of action, and predict effective drugs for pancreatic cancer and glioblastoma.

Ground state charge transfer is important for improving the photocatalytic performance of donor-acceptor type covalent organic frameworks (COFs), but it has been underexplored. Here, the authors report a COF with enhanced charge transfer, achieving a hydrogen evolution rate of 265 mmol g⁻¹ h⁻¹.

While inducing strain to noble metal nanomaterials can modulate catalytic activities, the strain is often spatially dependent. Here, authors manipulate the planar strain in noble metal nanosheets for hydrogen evolution electrocatalysis by constructing amorphous–crystalline phase boundaries.

Quantum memories are key components for quantum communication, but current storage times are still too short. Here, the authors use the atomic frequency comb protocol in a zero-first-order-Zeeman field to coherently store an optical pulse for an hour in a cryogenically cooled rare-earth doped crystal.

Synthetically replicating transmembrane protein signal transduction is a gaol of synthetic biology. Here, the authors show how the dimerization of synthetic transmembrane DNA receptors can be used to engineer sensing and actuation cascades in response to external molecular signals.

Atomic-level coordination influences the properties of single-atom-catalysts but is difficult to precisely engineer. Here, authors study the role of local symmetry manipulation, finding planar-symmetry-broken CuN₃ catalysts outperform highly symmetrical CuN₄ for CO₂ electroreduction to formic acid.

Lithium dendrite growth in solid-state electrolytes is a significant challenge for next-generation battery development. Here, authors used dark-field X-ray microscopy to investigate dislocations near dendrite tips, suggesting that stress-induced dislocation may influence dendrite branching and material fracture.

MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

The application and therapeutic success of CAR-T cell approaches are limited by the development of T cell exhaustion. Here, Stewart et al discover a role for IL-4 in driving CD8⁺ CAR-T cell exhaustion and demonstrate the improvement of CAR-T cell effectivity with interruption of IL-4 signalling.

Microcombs are vulnerable to the environmental perturbations. Here, the authors propose a universal mechanism to fully control the microcombs. Based this reconfigurable microsoliton, a wavemeter with a precision of kHz is demonstrated.

A sustainable photocatalytic methane halogenation strategy is developed for methyl halide production using low-cost alkali halides over Cu-doped TiO2 nanostructures. Copper sites ultimately stabilize *CH3 to promote reaction with Cl− to form CH3Cl.

Optoelectronic neural interfaces allow for non-genetic and remote modulation of neural activity. Here, the authors propose a biodegradable, flexible and miniaturized neural interface based on molybdenum-modified silicon diodes that allows transdermal neuromodulation and promotes nerve regeneration.

A unidirectional magnetoresistance observed in bilayer metal films could be used to add directional sensitivity to conventional magnetic sensors based on anisotropic magnetoresistance.

Solar-to-fuel conversion represents a renewable means to harvest sunlight, but the most efficient materials are often expensive or rare. Here, authors demonstrate gradient tantalum-doped hematite homojunctions as a method to improve photoelectrochemical water splitting performances.

It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality behaviours. Here we report a simulation of how improvements in four risk factors, namely smoking, alcohol use, physical activity and diet, could affect mortality. We show that in the ideal scenario, that is, all people who currently smokers quit smoking, excessive alcohol userswas reduced to moderate intake, people under 65 increased moderate physical activity by one hour and those aged 65 and older increased by half an hour per day, and all participants ate 200 g more fresh fruits and 50 g more fish/seafood per day, life expectancy at age 30 would increase by 4.83 and 5.39 years for men and women, respectively. In a more moderate risk reduction scenario referred to as the practical scenario, where improvements in each lifestyle factor were approximately halved, the gains in life expectancy at age 30 could be half those of the ideal scenario. However, the validity of these estimates in practise may be influenced by population-wide adherence to lifestyle recommendations. Our findings suggest that the current policy targets set by the Healthy China Initiative could be adjusted dynamically, and a greater increase in life expectancy would be achieved.

Lu et al. characterize cis-regulatory element dynamics at different stages of colorectal cancer progression and identify a functional variant associated with increased colorectal cancer risk because of selective transcription factor binding.

Nature’s oxygen-evolving complex of photosystem II is a multinuclear manganese cluster. Whether mononuclear manganese can also efficiently catalyse water oxidation has been a long-standing question. Now, Li and co-workers show that single atoms of manganese can be anchored on nitrogen-doped graphene to catalyse the oxygen evolution reaction. Credit: Water image Frankie Angel / Alamy Stock Photo.

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

High-throughput computational screening of multicomponent molecular photocatalytic systems offers a strategy to minimize the screening of large numbers of photosensitizer–catalyst combinations. Here a machine learning-accelerated approach using multiple descriptors shows strong predictive power in experimentally validated systems for CO₂ reduction.

CO2 hydrogenation has emerged as a sustainable alternative for side-chain alkylation of methyl groups. Here, the authors present the side-chain alkylation of 4-methylpyridine using CO2 hydrogenation as a substitute for methanol, facilitated by a Zn40Zr60O/CsX tandem catalyst.

Excessive production of reactive oxygen species (ROS) in cancer cells can induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that intermetallics modified with glucose oxidase and soybean phospholipid as nano-inducers promote cancer cell pyroptosis and disulfidptosis, resulting in ICD and anti-tumor immunity in preclinical models.

Electrocatalytic co-reduction of CO₂ and nitrate to synthesize urea is a sustainable and promising option to the alternative conventional Bosch-Meiser. Here, the authors report a CeO_x-integrated diatomic electrocatalyst overcomes the traditional trade-off between urea yield and Faradaic efficiency.

Ovarian metastases of gastric cancer are more likely to occur in young premenopausal women. Here authors show that estrogen regulates ovarian fibroblasts to promote ovarian metastasis of gastric tumors.

Geometric quantum gates—engineered evolution paths for qubit control—promise noise resilience but have shown limited fidelity in prior implementations in semiconductor quantum computation. Here the authors demonstrate high-fidelity single-qubit gates in a single-hole quantum dot in Ge, outperforming conventional dynamical gates.

While noble metal usage in catalysis is ubiquitous, the metals’ scarcity necessitates new materials designs for efficient utilization. Here, authors report a general strategy to prepare amorphous noble metal nanosheets and find the nanomaterials to act as efficient water-splitting electrocatalysts.

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

A hafnium oxide memristor crossbar array integrated with transistors can provide a provable key destruction scheme in which unique physical fingerprints are extracted by comparing the conductance of neighbouring memristors, and can only be revealed if a digital key stored on the same array is erased.

Photonic synthetic dimension (on TFLN chip) attracts broad interest. Here, authors achieve tunable couplings via MZI-linked resonators, and prove its versatility by realizing multiple models including tight-binding lattice, the Hall ladder and Creutz ladder along with their featured phenomena

Assembly of functional ribosomal subunits is aided by dedicated assembly factors. Here, the authors show that the Reh1 is positioned in the polypeptide exit tunnel of 80S ribosomes, suggesting that the growing polypeptide chain displaces Reh1 during first round of translation.

A computational model called Centaur, developed by fine-tuning a language model on a huge dataset called Psych-101, can predict and simulate human nature in experiments expressible in natural language, even in previously unseen situations.

Isolating purified electrosynthesis product is a major challenge in electrochemical carbon dioxide reduction. Here, the authors report a nanotwinned silver electrocatalyst and a pneumatic-trough cell system to produce a 52% concentrated CO, which is further utilized as a carbon feedstock for graphene production.

A bimolecular doping strategy enables the realisation of white organic polarized emissive semiconductor single crystals, emitting white light with a maximum degree of polarization as high as 0.96. Organic polarized light-emitting diodes and light-emitting transistors with tuneable emission wavelength are also demonstrated.

Cells contain isolated compartments that spatially confine different enzymes, enabling high-efficiency enzymatic cascade reactions. Herein, the authors report a cell-inspired design of biomimetic cascade catalysis system by immobilizing Fe single atoms and Au nanoparticles on the inner and outer layers of three-dimensional nanocapsules, respectively, to enable highly selective colorimetric glucose detection.

Regulating the adsorption behaviour of the polysulfide species is the key to achieving highly stable Li-S batteries. Here, the authors show that amorphization-induced redistribution of d orbitals enable CoO to be a favourable candidate for polysulfide adsorption and conversion.

Based on the correlation analysis of various omics data from Brassica napus L., authors identify one Flavobacterium strain C2 which mitigates P deficiency by regulating fatty acid metabolism and enhancing P uptake, indicating potential strategies to improve P utilization in rapeseeds.

Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.

Transcranial ultrasound stimulation (TUS) is a non-invasive method to modulate deep brain activity. Using direct recordings from implanted electrodes, we showed that TUS engages the human globus pallidus internus, with effects on neural oscillations and behavior.

By manipulating the interfacial barrier of CeO₂/SrTiO₃ heterostructure via oxygen stoichiometry, Li et al. report continuous linear control of the photoresponsivity in both positive and negative directions. The reconfigurable visible blind UV photodetector arrays are applied for in-sensor computing.

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synthesis, and delayed radial glial cell specification.

The success of Chimeric antigen receptor (CAR) T-cell therapy in solid tumours is hampered by the scarcity of suitable targets and suboptimal activation of the engineered T cells in the hostile microenvironment of the tumours. Here authors identify CD276 as target in childhood rhabdomyosarcoma, which, when combined into a bicistronic construct with a known target, FGF4R, allows enhanced tumour killing.

A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.

Phased array systems capable of beamforming at microwave frequencies can be created from large-area electronics based on zinc oxide thin-film transistors.