Nature Search

A soft robotic total artificial hybrid heart

End-stage heart failure remains a major clinical challenge with limited effective treatments. Here, the authors present a concept for a soft robotic total artificial heart with a biocompatible inner lining that shows native-like functions

Maziar Arfaee
Annemijn Vis
Jolanda Kluin
ResearchOpen Access03 Jun 2025
Nature Communications

Volume: 16, P: 1-14
Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells

The rational design and implementation of synthetic mammalian communication systems can unravel fundamental design principles of cell communication circuits and offer a framework for engineering of designer cell consortia with potential applications in cell therapeutics. Here the authors present a synthetic communication platform in mammalian cells based on diffusible dipeptide ligands and synthetic receptors, that is by design highly orthogonal, scalable, and programmable.

Anna-Maria Makri Pistikou
Glenn A. O. Cremers
Tom F. A. de Greef
ResearchOpen Access02 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation

In situ tissue engineered heart valve prostheses implanted in aortic position of an ovine model up to 12 months meet several hallmarks for sustainable heart valves prostheses, but variability in tissue remodelling and valve functionality are seen.

Annemijn Vis
Bente J. de Kort
Jolanda Kluin
ResearchOpen Access14 Nov 2023
Communications Biology

Volume: 6, P: 1-14
Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

This study presents a predictive equation for total energy expenditure derived from doubly labelled water measurements. Applying this equation to two large datasets (the National Diet and Nutrition Survey and National Health and Nutrition Examination Survey) shows that the misreporting of total energy intake is greater than 50%, with important implications for macronutrient availability.

Rania Bajunaid
Chaoqun Niu
John R. Speakman
ResearchOpen Access13 Jan 2025
Nature Food

Volume: 6, P: 58-71
Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

Janine Grolleman
Nicole C. A. van Engeland
Carlijn V. C. Bouten
ResearchOpen Access26 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Author Correction: Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

Rania Bajunaid
Chaoqun Niu
John R. Speakman
Amendments and CorrectionsOpen Access23 Apr 2025
Nature Food

Volume: 6, P: 523-524
Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Low total energy expenditure (TEE) has been a hypothesized risk factor for weight gain, but longitudinal repeatability of TEE is incompletely understood. Here the authors report that TEE is repeatable for adults, but not for children, and increases in TEE (adjusted for fat-free mass, fat mass, age and sex) are not associated with body composition changes in short-term longitudinal analyses.

Rebecca Rimbach
Yosuke Yamada
John R. Speakman
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-8
Bioengineering structural anisotropy in living tissues

Structural anisotropy is crucial for the function of various human tissues such as myocardial and locomotion muscles and cornea. In this Review, the authors summarize the development of structural anisotropy in native tissues and discuss in vitro reductionist approaches to understand and direct anisotropy for tissue regeneration applications.

Dylan Mostert
Cas van der Putten
Carlijn V. C. Bouten
Reviews30 Jul 2025
Nature Reviews Bioengineering

Volume: 3, P: 727-741
Evaluation of in situ tissue-engineered arteriovenous grafts suitable for cannulation in a large animal model

Vascular access for hemodialysis is often compromised by synthetic grafts that lack self-healing capabilities. Here, electrospun polycarbonate-bis urea grafts, reinforced with 3D-printed polycaprolactone coils, are shown to remodel into autologous tissue in goats.

Paul J. Besseling
Wojciech Szymczyk
Marianne C. Verhaar
ResearchOpen Access16 Jul 2025
Communications Materials

Volume: 6, P: 1-12
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

Nicole C. A. van Engeland
Freddy Suarez Rodriguez
Cecilia M. Sahlgren
ResearchOpen Access27 Aug 2019
Scientific Reports

Volume: 9, P: 1-14
Preclinical extracellular matrix-based treatment strategies for myocardial infarction: a systematic review and meta-analysis

van der Pol et al. present a systematic review and meta-analysis of the literature on the pre-clinical efficacy of extracellular matrix-based treatment strategies for myocardial infarction. Authors show improvements following extracellular matrix-based treatment strategies irrespective of species, sex or extracellular matrix source.

Atze van der Pol
Marijn C. Peters
Carlijn V. C. Bouten
ResearchOpen Access30 Mar 2025
Communications Medicine

Volume: 5, P: 1-16
Publisher Correction: Triple-marker cardiac MRI detects sequential tissue changes of healing myocardium after a hydrogel-based therapy

Maaike van den Boomen
Hanne B. Kause
Katrien Vandoorne
Amendments and CorrectionsOpen Access21 Feb 2020
Scientific Reports

Volume: 10, P: 1
Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

van Haaften et al. show numerical-experimental approach to reconstruct the graft–host response. They interrogate the mechanoregulation in dialysis grafts to solve the disturbed shear stress problem, which can be a cause of neointimal hyperplasia in blood vessels and grafts.

Eline E. van Haaften
Sjeng Quicken
Nicholas A. Kurniawan
ResearchOpen Access10 May 2021
Communications Biology

Volume: 4, P: 1-12
An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip

Nikita Subedi
Laura C. Van Eyndhoven
Jurjen Tel
ResearchOpen Access24 Aug 2021
Scientific Reports

Volume: 11, P: 1-11
In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D

A method is developed to engineer cerebral tissues with intact 3D neuronal networks, mimicking neuropathological signatures such as the propagation of epileptiform discharges, using a multi-chambered tissue culture chip.

Aref Saberi
Albert P. Aldenkamp
Carlijn V. C. Bouten
ResearchOpen Access23 Mar 2022
Communications Biology

Volume: 5, P: 1-9
Triple-marker cardiac MRI detects sequential tissue changes of healing myocardium after a hydrogel-based therapy

Maaike van den Boomen
Hanne B. Kause
Katrien Vandoorne
ResearchOpen Access18 Dec 2019
Scientific Reports

Volume: 9, P: 1-15
Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis

Suzanne E. Koch
Bente J. de Kort
Anthal I. P. M. Smits
ReviewsOpen Access23 Feb 2022
npj Regenerative Medicine

Volume: 7, P: 1-17
Growth and remodeling play opposing roles during postnatal human heart valve development

Pim J. A. Oomen
Maria A. Holland
Sandra Loerakker
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain

Chiara Tamiello
Carlijn V. C. Bouten
Frank P. T. Baaijens
ResearchOpen Access04 Mar 2015
Scientific Reports

Volume: 5, P: 1-10
Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective

Tamar B. Wissing
Valentina Bonito
Anthal I. P. M. Smits
ReviewsOpen Access16 Jun 2017
npj Regenerative Medicine

Volume: 2, P: 1-20

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