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Showing 1–4 of 4 results
Advanced filters: Author: Carlisle R. DeJulius Clear advanced filters

  • Allen et al. identify a pathogenic role for microbial small RNAs enriched on low-density lipoprotein to activate TLR8 signalling, thereby promoting polarization of inflammatory macrophages and facilitating the development of atherosclerosis.

    • Ryan M. Allen
    • Danielle L. Michell
    • Kasey C. Vickers
    Research
    Nature Cell Biology
    Volume: 24, P: 1701-1713

  • Modifications enhancing degradation resistance and albumin affinity enabled the delivery of an siRNA conjugate silencing MMP13 to guinea pig and murine arthritic joints, improving therapeutic outcomes following intravenous administration.

    • Juan M. Colazo
    • Megan C. Keech
    • Craig L. Duvall
    ResearchOpen Access
    Nature Biomedical Engineering
    Volume: 9, P: 1366-1383

  • This Review explores the potential of emerging RNA-based technologies and cell-engineering strategies, including those that incorporate small interfering RNA, microRNA, mRNA and synthetic receptor-mediated gene editing, to provide innovative and targeted approaches to osteoarthritis therapy.

    • Carlisle R. DeJulius
    • Bonnie L. Walton
    • Craig L. Duvall
    Reviews
    Nature Reviews Rheumatology
    Volume: 20, P: 81-100

  • Limited tumor cell delivery is a major challenge for the efficacious delivery of siRNAs to silence traditionally undruggable oncogenes. Here the authors optimize siRNAs for in situ binding to albumin through C18 lipid modifications and show the application of the lead conjugate structure for targeting MCL1 in orthotopic breast tumors in mice.

    • Ella N. Hoogenboezem
    • Shrusti S. Patel
    • Craig L. Duvall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20