Proteinuria results from defects in glomerular filtration, often as a result of kidney injury or inflammation. Sumant Chugh and his colleagues now show that the glycoprotein Angptl4 is highly upregulated in minimal change disease, a type of human proteinuria, and that genetic deletion protects against experimentally induced proteinuria in mice.
- Lionel C Clement
- Carmen Avila-Casado
- Sumant S Chugh
