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Showing 1–12 of 12 results
Advanced filters: Author: Carmen Sancho-Serra Clear advanced filters

  • A detailed spatiotemporal roadmap of the human female and male reproductive tracts during key periods of sexual differentiation provides new cellular and molecular insights into how early axial gradients lead to specific cell lineages and tissue structures.

    • Valentina Lorenzi
    • Cecilia Icoresi-Mazzeo
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 650, P: 428-437

  • The Human Endometrial Cell Atlas integrates single-cell transcriptomic datasets from women with and without endometriosis. Novel and known cell types are registered using spatial transcriptomics to provide a comprehensive map of the human endometrium in controls and endometriosis cases.

    • Magda Marečková
    • Luz Garcia-Alonso
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1925-1937

  • Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.

    • Matteo A. Molè
    • Tim H. H. Coorens
    • Magdalena Zernicka-Goetz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Hu et al. use single-cell RNA sequencing to explore the transcriptional profile of human amnion samples spanning the developmental window from Carnegie stage (CS)16 to CS23.

    • Wenqi Hu
    • Carmen Sancho-Serra
    • Magdalena Zernicka-Goetz
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 1175-1185

  • Irie, Lee et al. report a role for DMRT1 in human germline development and show that induction of DMRT1 in primordial germ cell-like cells triggers germline commitment, but suppresses pluripotency genes, thus promoting the onset of gametogenesis.

    • Naoko Irie
    • Sun-Min Lee
    • M. Azim Surani
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 1439-1452

  • A multiomics single-cell atlas of the human maternal–fetal interface including the myometrium, combining spatial transcriptomics data with chromatin accessibility, provides a comprehensive analysis of cell states as placental cells infiltrate the uterus during early pregnancy.

    • Anna Arutyunyan
    • Kenny Roberts
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 616, P: 143-151

  • This study provides a comprehensive spatiotemporal map of human and mouse gonadal differentiation, using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy, which can guide in vitro gonadogenesis.

    • Luz Garcia-Alonso
    • Valentina Lorenzi
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 607, P: 540-547

  • Single-cell and spatial transcriptomic profiling of the human endometrium highlights pathways governing the proliferative and secretory phases of the menstrual cycle. Analyses of endometrial organoids show that WNT and NOTCH signaling modulate differentiation into the secretory and ciliated epithelial lineages, respectively.

    • Luz Garcia-Alonso
    • Louis-François Handfield
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 1698-1711

  • The myeloid lineage is central to homeostasis and immunity. The authors provide an atlas of human iPSC-to-myeloid cell differentiation and demonstrate that the in vitro system recapitulates yolk sac differentiation, opening new avenues to human myelopoiesis.

    • Clara Alsinet
    • Maria Nascimento Primo
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus and show that genetic diversity and somatic mutations are present early in the benign disease.

    • Pierre Martinez
    • Margriet R. Timmer
    • Kausilia K Krishnadath
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10