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Showing 1–7 of 7 results
Advanced filters: Author: Carol A. Feghali-Bostwick Clear advanced filters

  • Systemic sclerosis (SSc) is a severe fibrotic disease that affects multiple organs, driven by vascular damage, inflammation and dysregulated repair. The authors of this Review explore the key mechanisms that promote fibrosis in SSc and highlight emerging therapeutic targets.

    • Jörg H. W. Distler
    • David Launay
    • Johann E. Gudjonsson
    Reviews
    Nature Reviews Rheumatology
    P: 1-18

  • Although autoimmune rheumatic diseases are more prevalent in women than men, few clinical trials report findings on the basis of sex and gender. Future clinical trials should report sex and gender differences in treatment and safety outcomes in a standardized manner to improve outcomes for all patients.

    • Elizabeth R. Volkmann
    • Carol Feghali-Bostwick
    Comments & Opinion
    Nature Reviews Rheumatology
    Volume: 21, P: 251-252

  • The diagnosis, treatment and management of systemic sclerosis (SSc) remains challenging, owing to the complexity of this disease. In this Perspective, an international group of experts discuss the future of SSc research and how the advent of innovative technologies will advance research into and understanding of SSc.

    • David J. Abraham
    • Carol M. Black
    • Thomas Krieg
    Reviews
    Nature Reviews Rheumatology
    Volume: 21, P: 174-187

  • Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.

    • Swati Bhattacharyya
    • Wenxia Wang
    • John Varga
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14