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Showing 1–15 of 15 results
Advanced filters: Author: Carolina Tropini Clear advanced filters

  • Here, the authors show that while species composition varies significantly across gut regions, genetic diversity within species is remarkably uniform and driven by similar strain frequencies along the gut lumen and global selective sweeps throughout the gut.

    • Michael Wasney
    • Leah Briscoe
    • Nandita Garud
    ResearchOpen Access
    Nature Communications
    P: 1-18

  • The gastrointestinal tract is a critical interface for microplastic and nanoplastic exposure, yet causal links to health outcomes remain uncertain. We outline current methodological challenges and provide a list of minimum standards for rigorous study design, standardized reporting and careful attention to interpretations to distinguish mechanism from signals.

    • Brian D. Deng
    • Sidhartha R. Sinha
    • Carolina Tropini
    Comments & Opinion
    Nature Reviews Gastroenterology & Hepatology
    P: 1-2

  • Microscopy methods that reveal the spatial patterns of individual types of microbe are limited by the number of different species that can be monitored together. A new technique now provides progress on this front.

    • Jen Nguyen
    • Carolina Tropini
    News & Views
    Nature
    Volume: 588, P: 591-592

  • The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial and micro-eukaryotic organisms optimize energy production in our body and ensure efficient metabolic function.

    • Carolina Tropini
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 84-85

  • In this Review, McCallum and Tropini discuss physical and biological factors that affect microbiota biogeography and organization at different scales, starting with an overview of the whole gut at the macroscale and then zooming in to the scale of host and microbial interactions.

    • Giselle McCallum
    • Carolina Tropini
    Reviews
    Nature Reviews Microbiology
    Volume: 22, P: 105-118

  • This digital PCR device arrays samples into one million small-volume reactors, achieving a dynamic range of 107, measurement precision better than 1% and the ability to detect single-nucleotide variants present at less than 1:100,000.

    • Kevin A Heyries
    • Carolina Tropini
    • Carl L Hansen
    Research
    Nature Methods
    Volume: 8, P: 649-651

  • Use of sophisticated reductionist and whole-system approaches are providing much-needed technologies to unravel the complex mélange of microbiome functions.

    • Dylan Dodd
    • Carolina Tropini
    • Justin L Sonnenburg
    News & Views
    Nature Biotechnology
    Volume: 33, P: 1238-1240

  • Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.

    • Alberto Caminero
    • Carolina Tropini
    • Elena F. Verdu
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 788-803

  • A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

    • Róbert Pálovics
    • Andreas Keller
    • Tony Wyss-Coray
    Research
    Nature
    Volume: 603, P: 309-314

  • This Review summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field.

    • Jack A. Gilbert
    • Meghan B. Azad
    • Rob Knight
    Reviews
    Nature Medicine
    Volume: 31, P: 1099-1113

  • Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

    • Nicholas Schaum
    • Benoit Lehallier
    • Tony Wyss-Coray
    Research
    Nature
    Volume: 583, P: 596-602