Rapid-acting antidepressant interventions, such as ketamine and psilocybin, are thought to enhance neural plasticity. This Review outlines evidence of synaptic deficits in individuals with major depressive disorder before discussing in vivo longitudinal studies of antidepressant-evoked structural plasticity in rodents. Translational opportunities, research gaps and challenges are also considered.
- Clara Liao
- Alisha N. Dua
- Alex C. Kwan
