Nature Search

Genome-wide association study reveals two new risk loci for bipolar disorder

Bipolar disorder (BD) is a severe mood disorder, which has been shown to have a large genetic component. Here the authors identify two previously unreported BD risk loci and provide further insights into the biological mechanisms underlying BD development.

Thomas W. Mühleisen
Markus Leber
Sven Cichon
Research11 Mar 2014
Nature Communications

Volume: 5, P: 1-8
Distribution of CFTR mutations in Saguenay– Lac-Saint-Jean: proposal of a panel of mutations for population screening

Anne-Marie Madore
Claude Prévost
Catherine Laprise
Research01 Mar 2008
Genetics in Medicine

Volume: 10, P: 201-206
A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population

Tarja Laitinen
Mark J. Daly
Juha Kere
Research01 May 2001
Nature Genetics

Volume: 28, P: 87-91
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

The authors perform meta-analysis of GWAS studies for asthma from multiancestral cohorts. They identify five new loci and find that the asthma-associated loci are enriched near enhancer marks in immune cells.

Florence Demenais
Patricia Margaritte-Jeannin
Dan L. Nicolae
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 42-53
The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population

C Laprise
Research20 Mar 2014
Genes & Immunity

Volume: 15, P: 247-255
An epigenome-wide association study of total serum immunoglobulin E concentration

A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a population sample has revealed associations at 36 loci that harbour genes encoding proteins including eosinophil products and phospholipid inflammatory mediators.

Liming Liang
Saffron A. G. Willis-Owen
William O. C. M. Cookson
Research18 Feb 2015
Nature

Volume: 520, P: 670-674
HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy

Anne-Marie Madore
Vanessa T Vaillancourt
Catherine Laprise
Research27 Feb 2013
European Journal of Human Genetics

Volume: 21, P: 1181-1184
Meta-analysis identifies seven susceptibility loci involved in the atopic march

The development of asthma following eczema is known as the atopic march. Here the authors conduct a GWAS on affected children and identify two novel loci associated with the disease phenotype.

Ingo Marenholz
Jorge Esparza-Gordillo
Young Ae Lee
ResearchOpen Access06 Nov 2015
Nature Communications

Volume: 6, P: 1-8
Exploring rare and low-frequency variants in the Saguenay–Lac-Saint-Jean population identified genes associated with asthma and allergy traits

Andréanne Morin
Anne-Marie Madore
Catherine Laprise
ResearchOpen Access11 Sept 2018
European Journal of Human Genetics

Volume: 27, P: 90-101
Longitudinal follow-up of the asthma status in a French–Canadian cohort

Marie-Eve Lavoie
Jolyane Meloche
Catherine Laprise
ResearchOpen Access13 Aug 2022
Scientific Reports

Volume: 12, P: 1-10
Deciphering the genetic structure of the Quebec founder population using genealogies

Laurence Gagnon
Claudia Moreau
Simon L. Girard
ResearchOpen Access04 Apr 2023
European Journal of Human Genetics

Volume: 32, P: 91-97
Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population

Héloïse Gauvin
Claudia Moreau
Marie-Hélène Roy-Gagnon
ResearchOpen Access16 Oct 2013
European Journal of Human Genetics

Volume: 22, P: 814-821
Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice

Cuillerier et al. investigate compensatory mechanisms underlying survival of mice with a liver-specific knockout of the mitochondrial mRNA-binding protein Lrpprc. They propose various mechanisms operating along the OXPHOS assembly line, including mitochondrial biogenesis, mitochondrial ribosome upregulation and preferential supercomplex assembly, that could compensate lack of LRPPRC and allow survival of these mice.

Alexanne Cuillerier
Matthieu Ruiz
Yan Burelle
ResearchOpen Access19 Aug 2021
Communications Biology

Volume: 4, P: 1-14

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Genome-wide association study reveals two new risk loci for bipolar disorder

Distribution of CFTR mutations in Saguenay– Lac-Saint-Jean: proposal of a panel of mutations for population screening

A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population

An epigenome-wide association study of total serum immunoglobulin E concentration

HLA-DQB102* and DQB106:03P* are associated with peanut allergy

Meta-analysis identifies seven susceptibility loci involved in the atopic march

Exploring rare and low-frequency variants in the Saguenay–Lac-Saint-Jean population identified genes associated with asthma and allergy traits

Longitudinal follow-up of the asthma status in a French–Canadian cohort

Deciphering the genetic structure of the Quebec founder population using genealogies

Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population

Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice

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