Nature Search

CREB3 gain of function variants protect against ALS

Cross-species transcriptomics on vulnerable neuronal populations unravels the transcription factor CREB3 and its regulatory network as resilience markers of ALS. Genetics and epidemiology further identify the protective rare variant CREB3R119G.

Salim Megat
Christine Marques
Caroline Rouaux
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

Single-cell RNA-sequencing technology gives access to cell cycle dynamics without externally perturbing the cell. Here the authors present DeepCycle,a robust deep learning method to infer the cell cycle state in single cells from scRNA-seq data.

Andrea Riba
Attila Oravecz
Nacho Molina
ResearchOpen Access23 May 2022
Nature Communications

Volume: 13, P: 1-13
Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm

This study shows the existence of three genetically different somite populations in amphioxus and suggests that the vertebrate head mesoderm is of lateral origin.

Daniel Aldea
Lucie Subirana
Hector Escriva
Research01 Jul 2019
Nature Ecology & Evolution

Volume: 3, P: 1233-1240
Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation

The role of TFIID core module TAFs (TATA-binding protein-associated factors) in embryogenesis is unknown. Here, the authors show that Taf4 is essential at mid-gestation and for complete neuronal differentiation of embryonic stem cells, but that Taf4a and Taf4b are redundant at early embryonic stages.

Diana Langer
Igor Martianov
Irwin Davidson
ResearchOpen Access30 Mar 2016
Nature Communications

Volume: 7, P: 1-16
Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells

Genome-wide binding profiles for eight different chromatin remodellers in mouse embryonic stem (ES) cells are determined at single nucleosome resolution; each remodeller binds at specific nucleosome positions relative to the start of genes, and the same remodeller acts as a positive or negative regulator of transcription depending on the promoter chromatin organization and epigenetic marking of the gene it binds.

Maud de Dieuleveult
Kuangyu Yen
Matthieu Gérard
Research27 Jan 2016
Nature

Volume: 530, P: 113-116
Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA

Trim24 and Trim33 are co-repressor complexes that suppress hepatocarcinogenesis. A new study now uncovers a function for Trim24 and Trim33 as repressors of VL30-type endogenous retroviruses in the liver. When derepressed, VL30 long terminal repeats (LTRs) function as promoter and enhancer elements deregulating expression of neighboring genes and generating noncoding enhancer RNAs that are required for LTR enhancer activity in hepatocytes.

Benjamin Herquel
Khalid Ouararhni
Irwin Davidson
Research03 Feb 2013
Nature Structural & Molecular Biology

Volume: 20, P: 339-346
Global transcription analysis of immature avian erythrocytic progenitors: from self-renewal to differentiation

Francesca Damiola
Céline Keime
Olivier Gandrillon
Research20 Sept 2004
Oncogene

Volume: 23, P: 7628-7643
Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature

Stéphanie Le Gras
Céline Keime
Karine Merienne
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment

Darya Yanushko
Beatriz German Falcon
Daniel Metzger
ResearchOpen Access26 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-12
In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice

Moïra Rossitto et al. find that exposure of pregnant mice to acetaminophen and ibuprofen leads to delayed meiosis in the germline of female offspring and accelerated ovarian aging in F2 females. Their results suggest the use of these analgesics in pregnancy may adversely affect female reproductive health spanning multiple generations.

Moïra Rossitto
Margot Ollivier
Brigitte Boizet-Bonhoure
ResearchOpen Access13 Aug 2019
Communications Biology

Volume: 2, P: 1-13
Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

Alexandre Henriques
Mylene Huebecker
Jean-Philippe Loeffler
ResearchOpen Access12 Jul 2017
Scientific Reports

Volume: 7, P: 1-15
The mouse HP1 proteins are essential for preventing liver tumorigenesis

Nehmé Saksouk
Shefqet Hajdari
Florence M. Cammas
Research04 Feb 2020
Oncogene

Volume: 39, P: 2676-2691

Search

CREB3 gain of function variants protect against ALS

Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation

Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells

Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA

Global transcription analysis of immature avian erythrocytic progenitors: from self-renewal to differentiation

Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature

p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment

In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

The mouse HP1 proteins are essential for preventing liver tumorigenesis

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