Nature Search

Ventral subicular pyramidal neurons contribute to epileptogenesis via anterior thalamic circuit

Suppressing ventral subicular glutamatergic neurons delays epileptogenesis, primarily through glutamatergic projections to the anterior thalamic nucleus.

Yiwei Gong
Shuo Zhang
Cenglin Xu
ResearchOpen Access26 Dec 2025
Communications Biology

Volume: 9, P: 1-13
The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology

The stress etiology of depression remains elusive. Here, authors show that dynorphin/KOR signaling-mediated impairment of excitatory synaptic transmission from claustrum to prelimbic cortex PV interneurons contributes to stress-induced depression.

Yu-Jun Wang
Gui-Ying Zan
Jing-Gen Liu
ResearchOpen Access30 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Histamine H₁ receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Social impairment and anhedonia are common negative symptoms in patients with schizophrenia. Here, the authors show that the histamine H₁ receptor in cholinergic neurons in the basal forebrain has a critical role in sensorimotor gating, social behaviour, and anhedonia-like behaviour in mice.

Li Cheng
Cenglin Xu
Zhong Chen
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-17
Discrete subicular circuits control generalization of hippocampal seizures

The subiculum is known to contribute to seizures in epilepsy. Here the authors investigate the circuit mechanism by which the subiculum contributes to initiation and propagation of hippocampal seizures in a mouse model.

Fan Fei
Xia Wang
Yi Wang
ResearchOpen Access25 Aug 2022
Nature Communications

Volume: 13, P: 1-17
A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.

Bin Chen
Cenglin Xu
Zhong Chen
ResearchOpen Access17 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Histamine H₁ receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

Neural mechanism underlying fear memory process is not fully understood. Here, the authors report that histamine H₁ receptor (H₁R) in medial septum cholinergic neurons is critical for contextual fear retrieval, serving as a promising target for related neurological disease.

Li Cheng
Ling Xiao
Zhong Chen
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-14
A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

Extracellular potassium levels in the brain can be correlated to neural activity. A selective potassium sensor, in which cations other than potassium are shielded by a membrane, can measure potassium concentration changes in the brain of freely moving mice undergoing epileptic seizures.

Jianan Liu
Fangyuan Li
Daishun Ling
Research10 Feb 2020
Nature Nanotechnology

Volume: 15, P: 321-330
Permethrin induces epileptic susceptibility via activation of Na⁺ channels and rise in glutamate

Environmentally relevant doses of permethrin activate Nav1.6 channels and lead to enhanced release of the excitatory neurotransmitter glutamate, which in turn increases seizure susceptibility and severity in both zebrafish and mice.

Ming Su
Yuansong Zhang
Li Li
ResearchOpen Access24 Nov 2025
Communications Biology

Volume: 8, P: 1-17
Activated astrocytes attenuate neocortical seizures in rodent models through driving Na⁺-K⁺-ATPase

Neocortical epilepsy is resistant to current treatments. Zhao et al. report that optogenetic stimulation of astrocytes effectively attenuates seizures via driving Na⁺-K⁺-ATPase, indicating a potential treatment strategy for intractable epilepsy.

Junli Zhao
Jinyi Sun
Yi Wang
ResearchOpen Access21 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

Yang Zheng
Cenglin Xu
Zhong Chen
ResearchOpen Access17 May 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
Low-frequency stimulation of the primary focus retards positive transfer of secondary focus

Yifang Kuang
Cenglin Xu
Zhong Chen
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
A glutamatergic innervation from medial area of secondary visual cortex to lateral posterior thalamic nucleus facilitates nociceptive and neuropathic pain

Optogenetics reveals the crucial role of glutamatergic neurons in the medial secondary visual cortex (V2M) in modulating nociceptive sensitivity and negative emotions under both physiological and neuropathic pain conditions.

Bei Tan
Xueqing Wu
Zhong Chen
ResearchOpen Access11 Mar 2025
Communications Biology

Volume: 8, P: 1-12
Thermo-sensitive micelles extend therapeutic potential for febrile seizures

Di Wu
Yangshun Tang
Yi Wang
ResearchOpen Access13 Aug 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits

Liying Chen
Yingwei Xu
Yi Wang
ResearchOpen Access07 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-16
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling

Bo Feng
Yangshun Tang
Zhong Chen
ResearchOpen Access23 Feb 2016
Scientific Reports

Volume: 6, P: 1-11

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