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Showing 1–7 of 7 results
Advanced filters: Author: Chai Ling Pang Clear advanced filters

  • Kanamori, Sato et al. develop SOF10, a humanized antibody that selectively blocks protease- and integrin αvβ8-mediated latent TGF-β1 activation. This selective blockade reduces fibrosis in multiple disease models, improves renal function, enhances anti-tumor immunity, and demonstrates safety in preclinical studies.

    • Masakazu Kanamori
    • Izumi Sato
    • Hideaki Shimada
    ResearchOpen Access
    Communications Medicine
    P: 1-16

  • Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.

    • Sock Hoai Chan
    • Yasmin Bylstra
    • Weng Khong Lim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Structural variations (SV) contribute to inter-individual variability. Here, the authors describe a first-generation multi-ancestry Asian SV catalogue containing 73,035 SVs from 8392 Singaporeans to provide insights into Asian SV diversity.

    • Joanna Hui Juan Tan
    • Zhihui Li
    • Nicolas Bertin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Sim, Tham et al. explore the combined predictive ability of clinical, retinal, and blood biomarkers for the prediction of cognitive decline in Southeast Asian memory clinic participants. Authors find that combining blood tests, eye markers, and clinical data may be a potential noninvasive tool for early risk detection for cognitive decline.

    • Ming Ann Sim
    • Yih Chung Tham
    • Christopher Li Hsian Chen
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-10

  • This Perspective article discusses Singapore’s efforts to implement a National Precision Medicine Strategy through the integration of genomic, clinical and lifestyle data of up to one million Singaporean individuals.

    • Eleanor Wong
    • Nicolas Bertin
    • Patrick Tan
    Reviews
    Nature Genetics
    Volume: 55, P: 178-186

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29