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Showing 1–3 of 3 results
Advanced filters: Author: Chanakha K Navaratnarajah Clear advanced filters

  • Structural and functional characterization of two neutralizing antibodies that target conserved, nonoverlapping epitopes in HeV and NiV F protein trimers and inhibit membrane fusion establishes the therapeutic potential of antibody cocktails to protect against henipavirus infection.

    • Ha V. Dang
    • Robert W. Cross
    • David Veesler
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 426-434

  • Binding of measles virus hemagglutinin (MVH) to its cellular receptors triggers the activation of the fusion protein. The conformational changes of MVH upon receptor binding are now examined by locking the dimers using disulfide bonds, or by pulling on appropriately positioned hexahistidine tags. The results indicate that the dimer interface is pulled apart after receptor binding by twisting of the MVH heads.

    • Chanakha K Navaratnarajah
    • Numan Oezguen
    • Roberto Cattaneo
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 128-134