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Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Xiao et al. report a weaker adaptive immune response in older adults after inactivated SARS-CoV-2 vaccination compared to young adult controls, identifying altered immune cell function and decreased antigen-specific receptor repertoire diversity as potential underlying mechanisms.

Chanchan Xiao
Zhiyao Ren
Guobing Chen
ResearchOpen Access13 Mar 2023
Nature Aging

Volume: 3, P: 418-435
Deep learning-enabled multiphoton microscopy predicts colorectal cancer recurrence from routine FFPE specimens

Yabing Yang
Chanchan Xiao
Wei Jiang
ResearchOpen Access18 Nov 2025
npj Digital Medicine

Volume: 8, P: 1-14
Multimodal tumor microenvironment signature of colorectal cancer for prediction prognosis and chemotherapy benefit

Wei Jiang
Kun Yang
Jun Yan
ResearchOpen Access02 Aug 2025
npj Precision Oncology

Volume: 9, P: 1-14
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty

Luo et al. report a single-cell landscape of human blood from newborn to frailty. Comprehensive profiling uncovers frailty-specific immune cells and gene expression signatures useful for formulating a clinically relevant screen for unhealthy aging.

Oscar Junhong Luo
Wen Lei
Guobing Chen
Research18 Apr 2022
Nature Aging

Volume: 2, P: 348-364
The shell shape optimization and fluid–structure interaction simulation of hose pump in water-fertilizer integrated fertilizer application

Xiao Ma
Lixin Zhang
Chanchan Du
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-16

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Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Deep learning-enabled multiphoton microscopy predicts colorectal cancer recurrence from routine FFPE specimens

Multimodal tumor microenvironment signature of colorectal cancer for prediction prognosis and chemotherapy benefit

Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty

The shell shape optimization and fluid–structure interaction simulation of hose pump in water-fertilizer integrated fertilizer application

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