Nature Search

IDO1 regulating ROS rhythm reveals glycogenolysis/PPP as a cancer treatment target

Increased reactive oxygen species (ROS) results in indoleamie-2,3-dioxygenase export to the cytosol, which converts tryptophan to kynurenine that binds glucose-6-phosphate dehydrogenase to enable NADPH production and ROS clearance.

Nannan Zhou
Zheng Ling
Bo Huang
Research13 Mar 2026
Nature Chemical Biology

P: 1-11
Revitalizing p-GSK-3β via cysteine sulfenylation promotes hepatic insulin resistance by differentially regulating glycogenesis and gluconeogenesis

ROS-mediated sulfenylation or ‘oxidative activation’ of p-GSK-3β can terminate glycogenesis and initiate gluconeogenesis by modulating Gys2 and FoxO1, leading to hepatic insulin resistance.

Jie Chen
Zhuohang Liu
Bo Huang
Research02 Apr 2026
Nature Metabolism

P: 1-16
Urea photosynthesis over a MOF-on-MOF S-scheme heterojunction

This study reports the design of a MOF-on-MOF heterojunction catalyst with interfacial dual active sites for efficient urea production via photocatalytic co-reduction of nitrate and carbon dioxide.

Yamin Xi
Chaoqi Zhang
Chao Liu
ResearchOpen Access06 Feb 2026
Nature Communications

Volume: 17, P: 1-12
Gasdermin E-mediated lysosome-pore formation curbs pancreatic ductal adenocarcinoma via IFN-γ/IFN-β/TGF-β cocktail mRNA-LNP

Yabo Zhou
Dianheng Wang
Bo Huang
Research30 Jan 2026
Cellular & Molecular Immunology

Volume: 23, P: 329-343
Hydrogen-bonded organic framework@conductive metal-organic framework heterostructures for ampere-level hydrogen peroxide production

Industrial-level electrochemical two-electron oxygen reduction reaction is promising for H₂O₂ production but lacks efficient catalysts. Here, the authors design a heterostructure catalyst for efficient H₂O₂ electrosynthesis at ampere-level current densities.

Yingying Zou
Yulin Zhang
Chengzhong Yu
ResearchOpen Access04 Dec 2025
Nature Communications

Volume: 16, P: 1-11
NEAT1 drives SARS-CoV-2 N protein–induced inflammation, metabolic reprogramming, and mitochondria–ER stress crosstalk

Cheng Qing
Huaigang Chen
Zhenguo Zeng
ResearchOpen Access25 Feb 2026
Scientific Reports

Volume: 16, P: 1-12
Sulfur cathodes for next-generation batteries

The global shift towards sustainable energy storage highlights sulfur-based conversion cathodes as promising candidates for next-generation batteries, yet commercialization remains elusive due to persistent limitations. In this Review, the authors critically assess challenges in scalable manufacturing and operation, identifying key bottlenecks and proposing strategic pathways to bridge laboratory research with real-world applications.

Alessandra Manzini
Irina Martynova
Andreu Cabot
ReviewsOpen Access10 Apr 2026
Communications Materials

Volume: 7, P: 1-26
Stable and high-yield hydrogen peroxide electrosynthesis from seawater

Hydrogen peroxide (H₂O₂) is a green oxidant with diverse applications. Aided by a nickel phosphorus trisulfide nanosheet electrocatalyst, this work shows a sustainable synthetic route to produce H₂O₂ from seawater with high yield and impressive stability.

Chaoqi Zhang
Pengyue Shan
Chengzhong Yu
Research01 Apr 2025
Nature Sustainability

Volume: 8, P: 542-552
Epitaxial growth of metal-organic framework nanosheets into single-crystalline orthogonal arrays

Constructing regular 3D superstructures from 2D nanosheets is a challenge. Here, the authors report the epitaxial growth of MOF nanosheets into single-crystalline orthogonal arrays with enhanced functional properties.

Yingying Zou
Chao Liu
Chengzhong Yu
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Ternary MOF-on-MOF heterostructures with controllable architectural and compositional complexity via multiple selective assembly

Assembly of MOF-on-MOF hybrids with complex structures and properties is of interest, but achieving sophisticated ternary heterostructures is challenging. Here, the authors synthesize three types of ternary MOF-on-MOF heterostructures with tunable complexity via a multiple selective assembly strategy.

Chao Liu
Qiang Sun
Chengzhong Yu
ResearchOpen Access02 Oct 2020
Nature Communications

Volume: 11, P: 1-8
An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma

Chaoqi Zhang
Guochao Zhang
Jie He
ResearchOpen Access04 Sept 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-10
Influence of plasma-enhanced combustion on RBCC engine using URANS

Wei-Rui Zhang
Yuan-Shu Liu
Rui Xue
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-22
Spin-modulated catalysis in sulfur cathodes for improved performance in lithium–sulfur batteries

Understanding the role of electronic spin states in electrodes is vital for improving battery performance. This Review discusses strategies to modulate spin states in electrocatalysts for conversion-type cathodes, with a focus on sulfur cathodes.

Chao Yue Zhang
Jing Yu
Andreu Cabot
ReviewsOpen Access18 Nov 2025
Communications Materials

Volume: 6, P: 1-33
TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2

Feng Wang
Chaoqi Zhang
Jie He
ResearchOpen Access02 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-12
Analysis of endoplasmic reticulum stress-related gene signature for the prognosis and pattern in diffuse large B cell lymphoma

Chaofeng Zhang
Qi Lin
Xiongpeng Zhu
ResearchOpen Access25 Aug 2023
Scientific Reports

Volume: 13, P: 1-15
PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway

Lingling Fang
Yun Che
Jie He
ResearchOpen Access11 Feb 2021
Cell Death Discovery

Volume: 7, P: 1-14
MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell

Yi Xin
Qin Yuan
Ding Yuan
ResearchOpen Access27 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Artificial topography changes the growth strategy of Spartina alterniflora, case study with wave exposure as a comparison

Hualong Hong
Minyue Dai
Chongling Yan
ResearchOpen Access17 Nov 2017
Scientific Reports

Volume: 7, P: 1-10

Search

IDO1 regulating ROS rhythm reveals glycogenolysis/PPP as a cancer treatment target

Revitalizing p-GSK-3β via cysteine sulfenylation promotes hepatic insulin resistance by differentially regulating glycogenesis and gluconeogenesis

Urea photosynthesis over a MOF-on-MOF S-scheme heterojunction

Gasdermin E-mediated lysosome-pore formation curbs pancreatic ductal adenocarcinoma via IFN-γ/IFN-β/TGF-β cocktail mRNA-LNP

Hydrogen-bonded organic framework@conductive metal-organic framework heterostructures for ampere-level hydrogen peroxide production

NEAT1 drives SARS-CoV-2 N protein–induced inflammation, metabolic reprogramming, and mitochondria–ER stress crosstalk

Sulfur cathodes for next-generation batteries

Stable and high-yield hydrogen peroxide electrosynthesis from seawater

Epitaxial growth of metal-organic framework nanosheets into single-crystalline orthogonal arrays

Ternary MOF-on-MOF heterostructures with controllable architectural and compositional complexity via multiple selective assembly

An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma

Influence of plasma-enhanced combustion on RBCC engine using URANS

Spin-modulated catalysis in sulfur cathodes for improved performance in lithium–sulfur batteries

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2

Analysis of endoplasmic reticulum stress-related gene signature for the prognosis and pattern in diffuse large B cell lymphoma

PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway

MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell

Artificial topography changes the growth strategy of Spartina alterniflora, case study with wave exposure as a comparison

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