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Pediatric Research (45)
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Research (53)

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Showing 1–50 of 53 results

Advanced filters: Author: Charles W. Leffler Clear advanced filters

Light/Dye Microvascular Injury Eliminates Pial Arteriolar Dilation in Hypotensive Piglets

Timothy H Eidson
Jamie L Edrington
Charles W Leffler
Research01 Jan 1995
Pediatric Research

Volume: 37, P: 10-14
Effects of Indomethacin on Cerebral Vasodilator Responses to Arachidonic Acid and Hypercapnia in Newborn Pigs

Charles W Leffler
Robert Mirro
Samuel Zuckerman
Research01 Jun 1993
Pediatric Research

Volume: 33, P: 609-614
Effect of Therapeutic Dose of Indomethacin on the Cerebral Circulation of Newborn Pigs

Charles W Leffler
David W Busija
Donathan G Beasley
Research01 Feb 1987
Pediatric Research

Volume: 21, P: 188-192
Pressure Ventilation Increases Brain Vascular Prostacyclin Production in Newborn Pigs

Robert Mirro
Charles W Leffler
David W Busija
Research01 Dec 1990
Pediatric Research

Volume: 28, P: 609-612
Effects of Indomethacin upon Cerebral Hemodynamics of Newborn Pigs

Charles W Leffler
David W Busija
Robert S Green
Research01 Nov 1985
Pediatric Research

Volume: 19, P: 1160-1164
Hypoxia Stimulates Prostacyclin Synthesis by Neonatal Lungs

Robert S Green
Charles W Leffler
Research01 Sept 1984
Pediatric Research

Volume: 18, P: 832-835
370 NOREPINEPHRINE (NE) CONCENTRATION-RESPONSE (C-R) RELATIONSHIPS IN KREBS-PERFUSED NEONATAL LAMB LUNG AND HIND LIMB

Robert S Green
Richard J Sheridan
Henrietta S Bada
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 172
371 EFFECT OF NOREPINEPHRINE (NE) ON VASCULAR PROSTACYCLIN (PGI₂) SYNTHESIS IN THE KREBS-PERFUSED NEONATAL LAMB LUNG AND HIND LEG

Robert S Green
Richard J Sheridan
Henrietta S Bada
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 172
369 COMPARISON OF TOLAZOLINE INHIBITION OF NOREPINEPH RINE (NE) CONSTRICTION OF NEONATAL HIRCINE PULMONARY AND FEMORAL ARTERIAL RINGS

Robert S Green
Charles W Leffler
Henrietta S Bada
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 172
Effects of Leukotrienes C₄, D₄, and E₄ on Cerebral Arteries of Newborn Pigs

David W Busija
Charles W Leffler
Donathan G Beasley
Research01 Oct 1986
Pediatric Research

Volume: 20, P: 973-976
Indomethacin Does Not Alter the Circulating Catecholamine Response to Asphyxia in the Neonatal Piglet

Robert S Green
Charles W Leffler
Donathan G Beasley
Research01 Jun 1987
Pediatric Research

Volume: 21, P: 534-537
Superoxide Scavengers Do Not Prevent Ischemia-Induced Alteration of Cerebral Vasodilation in Piglets

Charles W Leffler
Carolyn C Thompson
David W Busija
Research01 Feb 1993
Pediatric Research

Volume: 33, P: 164-170
Postasphyxial Increases in Prostanoids in Cerebrospinal Fluid of Piglets

Massroor Pourcyrous
Charles Leffler
David Busija
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 229-232
Evolution of microscopic heterogeneity and dynamics in choline chloride-based deep eutectic solvents

Tailoring the macroscopic properties of deep eutectic solvents requires knowing how these depend on the local structure and microscopic dynamics. The authors, with computational and experimental tools spanning a wide range of space- and timescales, shed light into the relationship between micro and macroscopic properties in glyceline and ethaline.

Stephanie Spittle
Derrick Poe
Joshua Sangoro
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Responses of Newborn Pig Pial Arteries to Sympathetic Nervous Stimulation and Exogenous Norepinephrine

David W Busija
Charles W Leffler
L Craig Wagerle
Research01 Nov 1985
Pediatric Research

Volume: 19, P: 1210-1214
A Comparison of the Sensitivities of Neonatal Ovine Pulmonary and Femoral Arteries to l-Norepinephrine Stimulation

Robert S Green
Charles W Leffler
Research01 Mar 1984
Pediatric Research

Volume: 18, P: 244-247
Cerebral Blood Flow Responses to Indomethacin in Awake Newborn Pigs

Massroor Pourcyrous
Charles W Leffler
David W Busija
Research01 May 1994
Pediatric Research

Volume: 35, P: 565-570
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
The role of intracavernosal vasoactive agents to overcome impotence due to spinal cord injury

C M Earle
E J Keogh
D J Lord
Research01 Apr 1992
Spinal Cord

Volume: 30, P: 273-276
Alterations in Cerebrovascular Reactivity after Positive Pressure Ventilation

Robert Mirro
Shantharama Karanth
Charles W Leffler
Research01 Jul 1992
Pediatric Research

Volume: 32, P: 114-117
mTADA is a framework for identifying risk genes from de novo mutations in multiple traits

Joint analysis of multiple traits can increase power and provide insights into shared genetic architecture. Here, Nguyen et al. develop multi-trait TADA (mTADA), an extension of TADA (transmission and de novo association test) that jointly analyses de novo mutations of traits for improved risk-gene identification power.

Tan-Hoang Nguyen
Amanda Dobbyn
Eli A. Stahl
ResearchOpen Access10 Jun 2020
Nature Communications

Volume: 11, P: 1-12
CHARACTERIZATION OF ALPHA-ADRENERGIC RECEPTORS IN NEONATAL PIGLET AORTAS BY RADIOLIGAND BINDING

Robert S Green
David W Busija
Charles W Leffler
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 235
The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis

Charles W Leffler
Jack R Hessler
Robert S Green
Research01 Oct 1984
Pediatric Research

Volume: 18, P: 938-942
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Integration of GWAS and single-cell transcriptomic data from the entire nervous system systematically identifies cell types underlying brain complex traits and provides insights into the etiology of Parkinson’s disease.

Julien Bryois
Nathan G. Skene
Patrick F. Sullivan
Research27 Apr 2020
Nature Genetics

Volume: 52, P: 482-493
Effects of Pancuronium Bromide on Cerebral Blood Flow Changes during Seizures in Newborn Pigs

Massroor Pourcyrous
Charles W Leffler
David W Buskja
Research01 Jun 1992
Pediatric Research

Volume: 31, P: 636-639
Pain-causing stinging nettle toxins target TMEM233 to modulate Na_V1.7 function

Voltage-gated sodium channels function as multiprotein signaling complexes. Here, authors show that the dispanin TMEM233 is essential for activity of stinging nettle toxins and that co-expression of TMEM233 modulates the gating properties of Na_V1.7.

Sina Jami
Jennifer R. Deuis
Irina Vetter
ResearchOpen Access28 Apr 2023
Nature Communications

Volume: 14, P: 1-16
A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus

In addition to rod and cone photoreceptors, the mammalian retina contains intrinsically photosensitive retinal ganglion cells (ipRGCs). Here the authors identify a population of ipRGCs that encode ventral vision.

Michael H. Berry
Michael Moldavan
Benjamin Sivyer
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Brain Superoxide Anion Generation in Asphyxiated Piglets and the Effect of Indomethacin at Therapeutic Dose

Massroor Pourcyrous
Charles W Leffler
David W Busua
Research01 Sept 1993
Pediatric Research

Volume: 34, P: 366-369
Increasing Ventilation Pressure Increases Cortical Subarachnoid Cerebrospinal Fluid Prostanoids in Newborn Pigs

Robert Mirro
William Armstead
Charles Leffler
Research01 Dec 1987
Pediatric Research

Volume: 22, P: 647-650
Cerebrovasodilatory Contribution of Endogenous Carbon Monoxide During Seizures in Newborn Pigs

Massroor Pourcyrous
Henrietta S Bada
Charles W Leffler
Research01 May 2002
Pediatric Research

Volume: 51, P: 579-585
75 EFFECT OF POLYETHYLENE GLYCOL-SUPEROXIDE DISMUTASE AND CATALASE ON BLOOD-BRAIN BARRIER PERMEABILITY AFTER ISCHEMIA-REPERFUSION IN THE NEWBORN PIG

Olivier P Thélin
Robert Mirro
Charles W Leffler
Research01 Sept 1990
Pediatric Research

Volume: 28, P: 289
COX-1 and COX-2 Contributions to Basal and IL-1β-Stimulated Prostanoid Synthesis in Human Neonatal Cerebral Microvascular Endothelial Cells

Helena Parfenova
Vladimir Levine
Charles W Leffler
Research01 Sept 2002
Pediatric Research

Volume: 52, P: 342-348
Preservation of Cerebrovascular Tone and Reactivity by Sodium Channel Inhibition in Experimental Prolonged Asphyxia in Piglets

Vladimir Levine
Massroor Pourcyrous
Charles W Leffler
Research01 Mar 2000
Pediatric Research

Volume: 47, P: 376-380
Dexamethasone Pretreatment Attenuates Cerebral Vasodilative Responses to Hypercapnia and Augments Vasoconstrictive Responses to Hyperventilation in Newborn Pigs

Kirsti Heinonen
Alexander Fedinec
Charles W Leffler
Research01 Feb 2003
Pediatric Research

Volume: 53, P: 260-265
The Effects of Treatment with Indomethacin on the Cerebral Vasculature of Newborn Piglets before and during Hemorrhagic Hypotension

Jane E Hayden
Charles W Leffler
Research01 Jan 1997
Pediatric Research

Volume: 41, P: 78-82
ENDOTHELIN-1 (ET-1) STIMULATES LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION BY PIGLET CEREBRAL MICROVASCULAR ENDOTHELIAL CELLS. † 1112

Momoh A. Yakubu
Karoly Liliom
Charles W. Leffler
Research01 Apr 1997
Pediatric Research

Volume: 41, P: 188
ROLE OF NITRIC OXIDE IN CEREBRAL VASCULAR TONE DURING HYPOTENSION IN NEWBORN PIGS. † 1272

Jane E Hayden
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 215
CEREBROSPINAL FLUID (CSF) CYCLIC AMP DURING CONTINUOUS INTRAVENOUS INFUSION OF DOPAMINE IN NEWBORN PIGS. 1418

Massroor Pourcyrous
Helena Parfenova
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 239
NEWBORN CEREBRAL MICROVASCULAR RESPONSES TO HYPERCAPNIA FOLLOWING PROTEIN KINASE C (PKC) AND PROTEIN TYROSINE KINASE (PTK) INHIBITION. † 1424

Ganapathy P Rama
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 240
The Effects of Partial Liquid Ventilation (PLV) on Cerebrovascular Hemodynamics in Newborn Pigs † 1725

Massroor Pourcyrous
Henrietta S Bada
Charles W Leffler
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 294
VASOACTIVE AGENTS STIMULATE ENDOTHELIN-1 (ET-1) PRODUCTION FROM ENDOTHELIAL CELLS VIA PROTEIN KINASE C. † 1111

Momoh A. Yakubu
Charles W. Leffler
Research01 Apr 1997
Pediatric Research

Volume: 41, P: 188
ENDOTHELIAL CYCLOOXYGENASE ACTIVITY IS REGULATED BY TYROSINE PHOSPHORYLATION IN THE NEWBORN PIG CEREBRAL CIRCULATION. † 999

Helena Parfenova
Liliya Balabanova
Charles W. Leffler
Research01 Apr 1997
Pediatric Research

Volume: 41, P: 169
COMPARISON OF LEFT- AND RIGHT-SIDED BRAIN BLOOD FLOW RESPONSES IN ASPHYXIATED NEWBORN PIGS WHEN A COMMON CAROTID ARTERY IS LIGATED. † 1417

Massroor Pourcyrous
Henrietta S Bada
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 239
THE EFFECTS OF TREATMENT WITH INDOMETHACIN IMMEDIATELY PRIOR TO HYPOTENSION ON THE CEREBRAL CIRCULATION OF NEWBORN PIGLETS. † 1273

Jane E Hayden
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 215
CYCLIC AMP IN CEREBROSPINAL FLUID (CSF) OF ASPHYXIATED HUMAN NEWBORNS.† 1419

Massroor Pourcyrous
Helena Parfenova
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 239
CYCLIC AMP IN CEREBROSPINAL FLUID (CSF) OF PRETERM INFANTS WITH INTRAVENTRICULAR HEMORRHAGE / POST-HEMORRHAGIC HYDROCEPHALUS (IVH/PHH).† 2259

Massroor Pourcyrous
Helena Parfenova
Charles W Leffler
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 379
The Effects of Intraventricular/Periventricular Blood on Cerebral 3′,5′-Cyclic Adenosine Monophosphate Concentration and Cerebrovascular Reactivity in Newborn Pigs

Massroor Pourcyrous
Helena Parfenova
Charles W Leffler
Research01 Sept 1997
Pediatric Research

Volume: 42, P: 305-310
Cerebrovascular Responses to Therapeutic Dose of Indomethacin in Newborn Pigs

Massroor Pourcyrous
David W Busija
Charles W Leffler
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 582-587
A novel locus of resistance to severe malaria in a region of ancient balancing selection

A multi-centre genome-wide association study of severe malaria in African children uncovers a new resistance locus close to a cluster of genes encoding glycophorins, which are receptors used by the malaria-causing parasite to invade red blood cells.

Gavin Band
Kirk A. Rockett
Victoria Cornelius
Research30 Sept 2015
Nature

Volume: 526, P: 253-257
Does prolonged severe hypercapnia interfere with normal cerebrovascular function in piglets?

Massroor Pourcyrous
Sandeep Chilakala
Charles W. Leffler
Research28 May 2018
Pediatric Research

Volume: 84, P: 290-295

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