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Rechargeable Li | |SOCl₂ battery performance is hindered by inadequate catalyst activity at the electrode. Here, authors utilize covalent organic frameworks with aligned pores and tailored chemistry to create localized high concentrations of iodine catalyst, achieving stable high-capacity cycling and good practical pouch cell performance.

Overcoming parasitic reactions between the electrolyte and electrodes is essential for realizing energy-dense lithium metal batteries. Here, the authors develop an oxygen distal fluorinated diluent that promotes a diluent- and anion-rich solvation structure, forming a stable inorganic-rich interphase and stable cycling in pouch cells at 500 Wh kg^–1 level.

Organophosphoryl compounds are important motifs, however regioselective phosphorylation of alkenes remains challenging. Here, the authors report a visible light driven triple catalytic strategy enabling radical Markovnikov hydrophosphorylation of unactivated alkenes via sequential reaction of (bis)homoallylic alcohols, Ph₂PCl, and water.

Organic electrode materials provide benefits including low cost, structural tunability, and flexibility, but are constrained by poor conductivity and solubility. Here, the authors synthesized a small-molecule organic cathode to strengthen intermolecular interactions and reduce solubility and assessed its performance as LiB and NaB cathodes at sub-zero temperature.

Dou and colleagues present DynNet, a biophysically informed deep learning framework that reconstructs continuous cellular dynamics from time-resolved single-cell data. DynNet maps cell fate transitions and offers insights into complex biological processes.

Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and organ dysfunction. Here, the authors show that lipid nanoparticles co-loaded with polydopamine and NUAK1 can reduce oxidative stress and inflammation, improving placental function and fetal growth in a preeclampsia mouse model.

The work presents a method to design grounded metamaterials whose displacement response remains unchanged under microstructure and shape reconfiguration, demonstrated experimentally using structures with tailored, mapping-invariant deformation behaviours.

Authors develop a general paradigm combining fluorescence resonance energy transfer imaging, gel electrophoresis and mass spectrometric analysis to identify and quantify intracellular N-acetylglucosamine modified glycoRNAs.

Chen et al. report a strategy of separating dipping and coating processes for fabricating highly conductive and comprehensive wearable graphene electronic fabrics. This low-cost methodology achieves 200-meter roll mass production, offering a universal platform for next-generation wearable technologies.

Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

Wu et al. show that cooperative coupling at buried and top perovskite interfaces promotes chemically bonded self-assembled monolayers and forms a stable 1D heterojunction, enabling perovskite solar cells with 27.05% efficiency and maintaining over 95% of the efficiency after 2,100-hour continuous operation at 65 °C.

Returned farside lunar anorthosites have compositions similar to nearside counterparts and show a 4.41-Ga zircon age, indicating globally comparable magma ocean solidification and constraining the crustal dichotomy to post-magma-ocean reworking.

It is useful to be able to determine the changes a material has undergone, but this is challenging in synthetic systems. Here, the authors report the development of a hydrogel materials conditioned by swelling, allowing determination of exposure to heat and salt by nucleation changes.

Atherosclerotic carotid stenosis leads to stroke, but how perivascular adipose tissue (PVAT) drives plaque instability is poorly understood. Here the authors show that PVAT harbours distinct ADSC subsets, with CD55⁺ADSCs promoting plaque angiogenesis via FGF2 and CXCL14⁺ADSCs enhancing inflammation, driving plaque destabilization.

Group 3 innate lymphoid cells (ILC3s) are key regulator of intestinal immunity. However, whether these cells drive necrotizing enterocolitis (NEC) and through which mechanism remains unexplored. Here, the authors employ a mouse model of neonatal NEC and implicate NKp46⁻CCR6⁻ double negative ILC3 autophagy in pathogenic ILC3 expansion and activation during NEC via HIF1a-modulation of glycolipid metabolism.

Host factor that restrain viral propagation offer new anti-RNA virus strategies. Here the authors provide evidence that endonuclease G (ENDOG) is a host anti-viral factor and engineer ENDOG expression on the mitochondrial outer membrane to eliminate viral RNA.

Liquid crystal elastomers are promising for actuators in soft robotics, but 3Dprinting methods often restrict responsive properties. Here the authors design by tuning the printing angle, affording a coiled fiber, for programmable actuation.

The preparation of bridged frameworks remains a formidable challenge, with most strategies relying on either linear multi-step syntheses or structurally special substrates. Here the authors report a bridged scaffold editing strategy of heterocycles and carbocycles, which employs formaldehyde and ureas in a multicomponent reaction, toward modular and efficient construction of diverse bridged polycycles.

Patients with hepatocellular carcinoma (HCC) with Vp4 portal vein tumour thrombus (PVTT) have poor prognosis and are underrepresented in clinical trials. Here, the authors report a phase 2 clinical trial evaluating first-line durvalumab (anti-PD-L1) plus HAIC-FOLFOX (hepatic arterial infusion chemotherapy) in patients with HCC with Vp4 PVTT, along with biomolecular and preclinical analysis.

Replicating the human brain’s imaginative ability has long been a core AI goal, yet current systems remain limited in speed and efficiency. Yang et al. present a hardware platform based on resistive memory, enabling high-speed, low-power AI content generation while fully preserving output quality.

Interfacial solvation structures are key to stable fast charging in Si anodes. Qiao and colleagues show that S-vacancy-driven anion-reduction catalysis regulates these structures to form a LiF-rich solid electrolyte interphase, enabling ultrafast charging and long cycle life.

Dysregulated CD59 drives uncontrolled complement activation in neuromyelitis optica spectrum disorders (NMOSD). Here, the authors show in a mouse NMOSD model that endothelial SPARC suppresses astrocytic CD59 by blocking the VEGFA/VEGFR2 axis, promoting astrocytopathy, that might offer a potential therapeutic strategy.

Self-healing materials typically suffer from poor mechanical properties due to the inherent trade-off between mechanical robustness and self-healing capability. Here the authors report a composite featuring an aligned array of hydroxyapatite nanowires interwoven with dynamic borate bond networks by a bidirectional freeze-drying method.

Telomeric systems are conserved across eukaryotes and may have originated over 1 billion years ago. Here the authors replaced yeast’s telomeres with a bacterial virus system, resulting in a stable functional assembly of DNA molecules up to 2.77 Mb, offering insights into the possible origins of telomeres.

After deep-space flight, rice seeds show increase in mutations and alteration in DNA and RNA modifications. Multi-omics and single-cell analyses suggest a transcription factor named SVT1 suppresses the differentiation of mutation-carrying cells via the MAPK pathway.

Protein-based bioplastics suffer from poor mechanical properties, limiting their use. Here, the authors report a coacervation based processing method for maize-derived zein protein which encourages β-sheet formation through shear-induced alignment, leading to high tensile strength films and fibres.

Soft tactile chips embed in-situ sensing in pneumatic actuators, improving teleoperation via adaptive haptic feedback. Liquid-metal pressure and pectin temperature sensors enable precise manipulation and better human-robot interaction.

Disordered orientations of the 1D component limit carrier transport in 1D/3D heterostructures. Chen et al. report bilayer interface engineering to induce vertically ordered 1D capping layers, enhancing charge transport, and achieving a certified efficiency of 26.0% with strong thermal and light stability.

Oxidative stress and dsRNA are key drivers of skin inflammation, while therapies targeting oxidative stress are common, dsRNA targeting is not. Here, the authors report on a cerium-doped polyoxometalate with anti-oxidative and dsRNA binding properties showing potential for a transdermal strategy to reduce skin inflammation.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

This study achieves ultrafast all-electrical perpendicular magnetization switching with a pulse width of 16 ps and an energy consumption of 41 fJ/bit in a CoTb/Ti/CoFeB/MgO heterostructure, enabled by combining the in-plane and out-of-plane spin current.

The high demand of soft strain sensors requires solutions to reduce resource waste. Here, the authors propose a machine learning framework that corrects unstable signals in soft strain sensors, making them more accurate, reliable and longer-lasting, and extending their usable lifetime by more than 3,000 times.

Single-component organic solar cells are more stable than blends but suffer limited efficiency from inefficient charge generation. Li et al. introduce a fluorinated double-cable polymer that accelerates charge transfer and separation, achieving 14.8% efficiency and higher photocurrent.

Concentration polarization limits cycling stability of cells at high currents. Here, authors propose a mechanical-electrochemical conversion strategy by constructing a piezo electrolyte that actively utilizes the unavoidable volume fluctuation of lithium metal to minimize concentration polarization.

How co-invading species facilitate one another remains largely unknown. This study shows that facilitation is often asymmetric and increases when co-invading plants differ in competitiveness and their ability to shape microbial communities.

In this work, the authors show that the uncharacterized protein YchJ acts as a ROS-sensing transcription factor in Salmonella; upon oxidation, YchJ dimerization represses rssB, stabilizing RpoS to activate antioxidant enzymes, protecting the pathogen from macrophage oxidative burst.

Immune checkpoint inhibitors combined with chemotherapy have demonstrated significant benefits in treating triple-negative breast cancer (TNBC). In this study, the authors present results from a randomized phase II trial evaluating the platinum-based and DNA-damaging agent carboplatin in combination with nivolumab in patients with metastatic TNBC.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Fu and colleagues present LUNAR, a self-supervised neural-physics method that reconstructs 3D molecular positions and optical aberrations directly from raw microscopy data, enabling calibration-free super-resolution imaging in complex biological samples.

The authors establish high-resolution spatiotemporal landscapes of AKI. They reveal that surviving epithelial cells are the primary drivers of kidney regeneration through proliferation, offering insights into the mechanism of kidney repair after AKI

Turning lignin oils into nylon ingredients is hard because key bonds resist breaking and products overreact. A light-driven catalyst makes cyclohexanones without added hydrogen and enables tougher, clearer polyamides.

Spatial transcriptomics platforms span multicellular to subcellular resolutions but lack methods to reconstruct single-cell transcriptomes across them. Here, the authors introduce STARS, a unified deep learning framework that integrates histology and transcriptomics to infer single-cell gene expression across resolutions.

scMethCraft is a computational toolkit for analysing single-cell DNA methylation data. It supports tasks such as cell clustering, data integration and data enhancement, enabling the discovery of epigenetic patterns across cell types.

RNA-binding proteins recognize RNA structures that vary across cell types and genetic variation. Here, the authors present BRIDGE, a model predicting RNA-protein interactions across contexts and explaining variant effects genome-wide.

Authors created a new evaluation framework called GPBench that compares large language models (LLMs) against general practitioners. They found that current LLMs are not suitable for autonomous deployment and still require human oversight.

This work develops a 3D-printed aluminium alloy with an Al₃Er nanoscale skeleton that deforms rather than breaks, achieving 700 MPa strength and 7% elongation, the mechanisms of which enable stronger lightweight structural metals.

Researchers develop a swellable polymer platform that immobilizes photocatalysts into flexible films and enables three-dimensional stacking architectures, boosting solar-driven hydrogen production and increasing energy output per unit area.

This study finds that the most dangerous tick-borne viruses infect many tick and animal species, boosting their chances of reaching humans. Bird migration helps spread them worldwide, and genetic adaptation may increase their ability to infect people.

Efficient hydrogen storage and catalysis rely on understanding how hydrogen atoms move across catalyst surfaces. This study identifies electronic descriptors that govern hydrogen spillover, enabling the rational design of high-performance catalysts.