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Mechanisms of Okanin against wound healing based on network pharmacology, molecular docking and molecular dynamics simulation

Chenzi Zhao
Yang Li
Jing Wang
ResearchOpen Access02 Dec 2025
Scientific Reports

Volume: 15, P: 1-21
Low-dose AAV-CRISPR-mediated liver-specific knock-in restored hemostasis in neonatal hemophilia B mice with subtle antibody response

Here, the authors develop an AAV-CRISPR mediated somatic knock-in. They apply this system to restore hemostasis in neonatal hemophilia B mice and show liver-specificity of the knock-in and low serum antibody production.

Xiangjun He
Zhenjie Zhang
Bo Feng
ResearchOpen Access25 Nov 2022
Nature Communications

Volume: 13, P: 1-17

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Mechanisms of Okanin against wound healing based on network pharmacology, molecular docking and molecular dynamics simulation

Low-dose AAV-CRISPR-mediated liver-specific knock-in restored hemostasis in neonatal hemophilia B mice with subtle antibody response

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