Nature Search

A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines

The authors present Gemini, their bifunctional replicon platform capable of functioning as either self-amplifying RNA (saRNA) or self-amplifying DNA (saDNA).

Wilfred A. Jefferies
Kyung Bok Choi
Cheryl G. Pfeifer
ResearchOpen Access22 Dec 2025
Nature Communications

Volume: 16, P: 1-21
Characterization of the oligomerization defects of two p53 mutants found in families with Li–Fraumeni and Li–Fraumeni-like syndrome

Timothy S Davison
Peter Yin
Cheryl H Arrowsmith
Research10 Aug 1998
Oncogene

Volume: 17, P: 651-656
The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain

Maciej J. Lazarczyk
Brett A. Eyford
Dara L. Dickstein
ResearchOpen Access20 Apr 2023
Scientific Reports

Volume: 13, P: 1-10
A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion

A study reveals that unique subtypes of innate lymphoid cells (ILC2s) contribute to diverse functions 53 such as tissue remodeling, immune responses, and anti-tumor CTL responses, challenging current 54 understandings of ILC2 biology.

Clara Wenjing Xia
Iryna Saranchova
Wilfred A. Jefferies
ResearchOpen Access03 Jan 2024
Communications Biology

Volume: 7, P: 1-15
Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Beatson et al. show that a sialylated tumour-associated glycoform of the mucin MUC1 induces the differentiation of monocytes into tumour-associated macrophages. These macrophages are found in breast cancer stroma and their presence is associated with poor prognosis.

Richard Beatson
Rosalind Graham
Joy M. Burchell
ResearchOpen Access04 Nov 2020
Communications Biology

Volume: 3, P: 1-15
Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons

Brett A. Eyford
Maciej J. Lazarczyk
Wilfred A. Jefferies
ResearchOpen Access11 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis

Iryna Saranchova
Jeffrey Han
Wilfred A. Jefferies
ResearchOpen Access13 Feb 2018
Scientific Reports

Volume: 8, P: 1-17
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33

Iryna Saranchova
Jeffrey Han
Wilfred A. Jefferies
ResearchOpen Access13 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Serum free culture for the expansion and study of type 2 innate lymphoid cells

Pablo de Lucía Finkel
Christopher Sherwood
Wilfred A. Jefferies
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-10

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