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Showing 1–10 of 10 results
Advanced filters: Author: Cheryl Lyn Walker Clear advanced filters

  • This Opinion article discusses how alterations to epigenetic programmes during development (including in the uterus), which may arise from exposure to hormones, can increase the risk of developing metabolic diseases and cancer in adulthood.

    • Cheryl Lyn Walker
    • Shuk-mei Ho
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 479-486

  • Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet.

    • Lindsey S. Treviño
    • Jianrong Dong
    • Cheryl Lyn Walker
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Reactive oxygen species inhibit mTORC1 signalling, but the subcellular localization of this event has been unclear. Walker and colleagues show that the tuberous sclerosis complex (TSC) is located at the peroxisome, where it functions as a Rheb GTPase-activator protein to suppress mTORC1 and induce autophagy. They also show that disease-associated mutations in TCS2 display impaired peroxisome localization and mTORC1 repression.

    • Jiangwei Zhang
    • Jinhee Kim
    • Cheryl Lyn Walker
    Research
    Nature Cell Biology
    Volume: 15, P: 1186-1196

  • Zhang et al. report that in response to ROS, ATM regulates peroxisome homeostasis through the phosphorylation of PEX5, which is then ubiquitylated and can be recognized by p62 to specifically activate pexophagy.

    • Jiangwei Zhang
    • Durga Nand Tripathi
    • Cheryl Lyn Walker
    Research
    Nature Cell Biology
    Volume: 17, P: 1259-1269

  • Precision environmental health leverages environmental and system-level data to understand underlying environmental causes of disease, identify biomarkers of exposure, and develop new prevention and intervention strategies. In this Perspective, the authors provide real-life illustrations of the utility of precision environmental health approaches and identify current challenges in the field.

    • Andrea Baccarelli
    • Dana C. Dolinoy
    • Cheryl Lyn Walker
    ReviewsOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • The molecular features that define the initiation and progression of clear cell renal cell carcinoma (ccRCC) are being increasingly defined. This Review summarizes common genomic and chromosomal copy number abnormalities in ccRCC, providing a mechanistic framework with which to organize these features into initiating events, drivers of progression and factors that confer lethality.

    • Eric Jonasch
    • Cheryl Lyn Walker
    • W. Kimryn Rathmell
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 245-261