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Showing 1–8 of 8 results

Advanced filters: Author: Chi-Ming Wong Clear advanced filters

Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism

Tetrandrine is one of the most potent inhibitors of Ebola Virus infection. Here the authors identify LIMP-2 as a direct cellular target of Tetrandrine and establish a functional connection between lysosomal sphingosine homeostasis and calcium regulation.

Wing-Cheung Chan
Qian Zhao
Ben C. B. Ko
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-21
Exploring the limit of using a deep neural network on pileup data for germline variant calling

A lack of accurate and efficient variant calling methods has held back single-molecule sequencing technologies from clinical applications. The authors present a deep-learning method for fast and accurate germline small variant calling, using single-molecule sequencing data.

Ruibang Luo
Chak-Lim Wong
Tak-Wah Lam
Research06 Apr 2020
Nature Machine Intelligence

Volume: 2, P: 220-227
MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity

Pallavi Asthana
Liguo Li
Hoi Leong Xavier Wong
ResearchOpen Access23 Sept 2025
Cell Discovery

Volume: 11, P: 1-17
Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

Bin Li
Min Yuan
Hui-Kuo G Shu
Research12 Apr 2004
Oncogene

Volume: 23, P: 4594-4602
β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H

Yun Cheng
Wei-Wei Gao
Dong-Yan Jin
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-16
Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor

Hei-Man Vincent Tang
Kewu Pan
Dong-Yan Jin
ResearchOpen Access20 Jan 2015
Scientific Reports

Volume: 5, P: 1-11
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

Ashok Iyaswamy
Abhimanyu Thakur
Min Li
ResearchOpen Access23 Oct 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy

Zhou Zhu
Liang-feng Liu
Min Li
Research25 Feb 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2511-2526