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Applications of optical laser-based techniques are limited by the long wavelengths of the lasers. Now, observations of phonons and thermal transport at nanometre length scales are reported with an all-hard X-ray transient-grating spectroscopy technique.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Seismological and geodetic data are used together with a machine learning earthquake catalogue to reconstruct magma migration before and during the 2025 volcano–tectonic crisis at Santorini volcano, indicating a coupling between Santorini and Kolumbo.

In this meta-analysis of the fibrotic hand disorder Dupuytren’s disease, the authors identify genetic risk variants, study them for their functional consequences and implicate two signaling pathways involved in the disease mechanism of this debilitating disorder.

Methane dissociated from the base of the hydrate stability zone off Mauritania during warm interglacials travelled up to 40 km landward beyond where methane hydrates are typically found before venting out, according to 3D seismic imagery.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A gate electrode is normally required to perform tunable transport measurement via scanning tunnelling microscopy. Here, the authors use the tip of the microscope itself as the gate, inducing band bending in zinc oxide, and is used to study charging transitions, binding energies and vibrational excitations.

Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of energy balance.

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

Methane release rate from Arctic Ocean sediments in winter is significantly lower than in summer, according to surveys of cold-seep activity along the shelf break offshore Svalbard.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesity. They identify four loci newly associated with height and seven loci newly associated with clinical obesity and find overlap in the genetic structure and distribution of variants identified for these extremes of the trait distributions and for the general population.

Widespread shallow-water hydrothermal venting in the North Atlantic, probably a source of methane, coincided with the onset of the Palaeocene–Eocene Thermal Maximum, according to borehole proxy records and seismic imaging.

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Spin-crossover complexes often lose their functionality upon adsorption on metal surfaces. Here, a metal–organic complex adsorbed on a silver surface undergoes reversible interlocked spin and coordination switching, which is enabled by an intramolecular feedback mechanism controlling the position of an axial ligand strapped to the complex.

The authors use seismic and sedimentology data to estimate the volume of the Minoan eruption. The results show that the Plinian phase contributed most to the distal tephra fall, and that the pyroclastic flow volume is significantly smaller than previously assumed.

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

In bacteria Zn2+-dependent deacylases are underexplored. Here, the authors identify bacterial deacylases, providing systemic structure-function analyses to reveal the basis of substrate specificity, acyl-chain preference and inhibition.

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

This very large genome-wide association study identifies hundreds of new genetic variants influencing adult height in at least 180 loci enriched for genes involved in skeletal growth defects. The results show that the likely causal gene is often located near the most strongly associated variant, that many loci have multiple independently associated variants and that associated variants are enriched for likely functional effects on genes.

Three-dimensional seismic data is used to reconstruct the flank collapse of Kolombo volcano in 1650, which led to a catastrophic tsunami event.

Methanotrophic bacteria can consume methane emitted from the ocean floor before it reaches the atmosphere. Variations in coastal currents can reduce methane oxidation in the ocean by limiting methanotroph residence time above methane seeps.

Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, several of which show stronger effects in women than in men.

There is a strong correlation between submarine slope failures and the occurrence of gas hydrates. Here, the authors use a combination of seismic data and numerical modelling to show that overpressure at the gas hydrate stability zone leads to potential destabilization of the slope and submarine landslides.

Turbidity currents are driven by surge dynamics within their frontal cell, with fast surges from behind providing momentum, sustaining flow fronts for <1,000 km, as revealed by ocean-bottom seismometer data documenting their internal speed and structure.

The tsunami from the Storegga slide 8,150 years ago was caused by a smaller submarine landslide than previously thought, which implies higher hazard in the region, according to analyses of geophysical data and sediment cores that suggest an older origin of part of the scar.

Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

A tethered macrocyclic peptide antibiotic class described here—which shows potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii—blocks the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane through inhibition of the LptB₂FGC complex.

The conductance of a single C₆₀ molecule depends on the number of atoms in the electrodes that are in direct contact with the molecule.

Upregulation of PI(3)K signaling pathways is implicated in many diseases, and a number of inhibitors are currently in clinical development. The structure of a PI(3)Kδ kinase domain, along with co-complexes with a diverse range of inhibitors, reveals new insights into mechanisms of inhibition and suggests isoform-selective design strategies.

Triggers of gas hydrate instability along continental margins remain debated. Here, via numerical simulations, the authors show that pulses in sedimentation, rather than bottom water temperature or sea level change, likely triggered gas hydrate dissociation offshore Norway at the end of the last glaciation.

Pyramidanes are curious molecules. The tetrahedranes and the [4]–[6]pyramidanes exhibit molecular structures derived from trigonal to hexagonal pyramids. Examples of these pyramidanes are presented and their structural, spectroscopic and chemical features are described.

Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.

Joel Hirschhorn and colleagues report results of a large-scale genome-wide association and replication study for obesity-related traits. The newly discovered loci are enriched for genes expressed in the central nervous system, and may thus contribute to weight gain by modulating food intake. Similar results are reported in a related study by Gudmar Thorleifsson and colleagues.

A meta-analysis of genome-wide association studies of phenotypic variation for height and body mass index in human populations using 170,000 samples shows that one single nucleotide polymorphism at the FTO locus, which is associated with obesity, is also associated with phenotypic variation.

Carbonization of a self-assembled monolayer of a hexayne amphiphile at the air/water interface at room temperature results in the formation of functional carbon nanosheets. The nanosheets exhibit a molecularly defined thickness, are mechanically self-supporting over several micrometres, and have macroscopic lateral dimensions on the order of centimetres.

Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

Rachael Stolzenberg-Solomon, Laufey Amundadottir and colleagues report a genome-wide association study of pancreatic cancer. They identify four new susceptibility loci.

An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.