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Showing 1–10 of 10 results
Advanced filters: Author: Christian Kukat Clear advanced filters

  • How the developing skin epidermis is transformed from a simple single-layered epithelium to a complex and stratified barrier is still an open question. Here, the authors provide a model based on high proliferation and delamination of the keratinocyte progenitors that support the stratification process.

    • Mareike Damen
    • Lisa Wirtz
    • Hisham Bazzi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Maintenance and quality control of the mitochondrial respiratory chain complexes responsible for bulk energy production are unclear. Here, the authors show that the mitochondrial protease ClpXP is required for the rapid turnover of the core N-module of respiratory complex I, which happens independently of other modules in the complex.

    • Karolina Szczepanowska
    • Katharina Senft
    • Aleksandra Trifunovic
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • The community-driven initiative Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy (QUAREP-LiMi) wants to improve reproducibility for light microscopy image data through quality control (QC) management of instruments and images. It aims for a common set of QC guidelines for hardware calibration and image acquisition, management and analysis.

    • Ulrike Boehm
    • Glyn Nelson
    • Roland Nitschke
    Comments & Opinion
    Nature Methods
    Volume: 18, P: 1423-1426

  • Age impacts the effect of dietary health and longevity interventions but the underlying mechanisms are incompletely understood. Here the authors study fasting in killifish and find that older animals exhibit a metabolic shift resembling a fasting-like program, which is counteracted by boosting the activity of AMPKγ1, promoting health and longevity.

    • Roberto Ripa
    • Eugen Ballhysa
    • Adam Antebi
    ResearchOpen Access
    Nature Aging
    Volume: 3, P: 1544-1560

  • Mutations in the hexosamine pathway key enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) improve protein quality control and extend C. elegans lifespan. Here the authors present the crystal structures of full-length human GFAT-1 alone and with bound ligands and perform activity assays, which show that gain-of-function in the longevity-associated G451E variant is caused by a loss of feedback regulation.

    • Sabine Ruegenberg
    • Moritz Horn
    • Martin S. Denzel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16