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The realization of a two-dimensional quadrupole topological insulator—featuring gapless corner states but an otherwise insulating bulk and edge—establishes electrical circuits as a versatile platform for implementing topological band structures.

By examining the dynamics of skyrmions and antiskyrmions using a combination of atomistic spin simulations, reduced-variable modelling and machine learning algorithms, it is shown that current-induced spin–orbit torques can lead to trochoidal motion and skyrmion–antiskyrmion pair generation.

During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism towards production of purines and thus compensates for their loss.

Oblivious transfer is a standard primitive for cryptography between two parties which do not trust each other. Here, the authors propose a continuous-variable protocol which is secure against a dishonest party with bounded quantum storage capacity, and realize a proof-of-principle implementation.

Free electron laser beam profile characterization is usually performed separately from the actual measurements and this leads to considerable uncertainty in the results. Here the authors demonstrate the simultaneous measurement of the FEL beam profile with the experiment by using integrated gratings.

Active matter describes a group of interacting units showing collective motions by constantly consuming energy from the environment, but inertia has largely been overlooked in this context. Scholz et al. show how important it can be by characterizing the dynamics of self-propelled particles in a model system.

Binding and unbinding kinetics are important determinants of protein-protein or small molecule protein functional interactions that can guide drug development. Here the authors exploit the multi-ensemble Markov model framework to develop a computational approach that allows the estimation of binding kinetics reaching into the seconds timescale.

The discovery of topological insulators has given rise to a flourishing field dedicated to the investigation of the topological state of matter. This manuscript contributes to this field by introducing the idea of a topoelectrical circuit, whereby an assembly of conventional circuit elements realises various topological band structures.

It is unclear whether CO₂-stimulation of photosynthesis can propagate through slower ecosystem processes and lead to long-term increases in terrestrial carbon. Here the authors show that CO₂-stimulation of photosynthesis leads to a 30% increase in forest regrowth over a decade of CO₂ enrichment.

The entropy of a few-electron quantum system is measured for the first time by tracking the movement of charge in and out of the system. This could allow the unambiguous detection of Majorana fermions in solid state devices.

For molecular magnets and qubits, coupling between vibrations and electronic spins has a strong influence on spin state lifetime. Here, Kragskow et al present direct measurements of the vibronic transitions in a molecular magnet, showing the critical role of an “envelope effect” in the spectra.

Full cosmological hydrodynamical simulations employing modified gravity find that disk galaxies can form and their stellar properties are only mildly affected. Modified gravity leaves signatures on large-scale structure observable with the Square Kilometre Array.

The Yu-Shiba-Rusinov state, arising from exchange coupling between a magnetic impurity and a superconductor, undergoes a quantum phase transition at a critical coupling. In a scanning tunnelling microscopy experiment, Karan et al. reveal distinct tunnelling spectra on each side of the transition in a magnetic field, which allows them to distinguish the free spin regime from the screened spin regime.

Understanding excitonic optical excitations is integral to improving optoelectronic and photovoltaic semiconductor devices. Here, Bennecke et al. use photoemission exciton tomography to unravel the multiorbital electron and hole contributions of entangled excitonic states in the prototypical organic semiconductor C60.

A magnetic impurity is placed on the tip of a scanning tunnelling microscope, allowing direct tunnelling between two Yu–Shiba–Rusinov bound states. This technique can probe and enhance the impurity state lifetime.

Accelerating electrons to high energy and controlling their properties on ultrafast timescales is challenging. Here the authors show controlled acceleration of electron bunches using forward scattering in the resonantly enhanced polarization field of silver clusters driven by a phase-tuned two-color laser field.

Researchers have fired ultracold-atom Bose–Einstein condensates towards the submicrometre-featured potentials formed by the optical near-fields of surface plasmons. The strength and structural dependence of the optical near-fields were determined from the reflection of cold atoms. It is hoped that the work paves the way towards plasmonic guiding and the manipulation of cold atoms.

Single photon ionization—one of the most fundamental light matter interactions—can be significantly altered in a strong-field environment. Here the authors demonstrate a self-probing spectroscopy technique, resolving the evolution of the interaction in helium atoms with attosecond precision.

Magnetic impurities on superconductors lead to bound states within the superconducting gap, so called Yu-Shiba-Rusinov (YSR) states. Here, the authors study tunneling from a vanadium STM tip to a V(100) surface and show that YSR states can be excited at very low temperature by applying a microwave signal.

Control of spins down to the atomic scale is a major goal for spin-based information processing. Here, Kot et al. demonstrate electric control over the spin-resonance transitions of a single TiH molecule placed on a surface of MgO by exploiting the electric field between the scanning tunnelling microscopy tip and the sample.

Transmitters and receivers based on plasmonic internal-photoemission detectors are developed for optoelectronic terahertz signal processing and monolithically integrated on a silicon chip. Proof-of-concept experiments are demonstrated.

A quark–gluon plasma is produced in proton–gold, deuteron–gold and helium–gold collisions. Observing elliptic and triangular flow in this nearly inviscid fluid from these different initial geometries provides a unique benchmark for hydrodynamic models.

The synchronisation of optical cavities in the quantum regime is still relatively unexplored. Here, Kreinberg et al. investigate the coupling behaviour of two quantum dot microlasers and find that spontaneous emission noise from cavity QED effects plays an important role.

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

Spin-crossover molecules offer a potential route towards molecular spintronics, but retaining the bistability of the spin state upon surface deposition is challenging. Here, the authors study the spin-crossover behaviours of an Fe(II) complex deposited on graphite, determining the scale limit at which cooperative spin switching becomes effective.

Standard approaches for heritability and set testing in statistical genetics rely on parametric models that might not hold in reality and give inflated p-values. Here, the authors develop a fast method for permutation-based testing of marker sets and of heritability that does not suffer from model misspecification.

A study of patients with COVID-19 and healthy donors found CD4⁺ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined.

In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

While the physics of freezing water droplets are known, it is less known how bubbles freeze. The authors investigate the physics of freezing soap bubbles and identify two distinct freezing modes, depending on whether the surroundings are warmer or colder than the melting temperature.

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.

Combining X-ray structures, surface plasmon resonance and hydrogen-deuterium exchange–mass spectrometry, a class of highly selective inhibitors was found to bind to an active state of PI3Kγ breaking a conformational ‘lock’ important for activation of PI3Kγ.

Magnetoencephalography (MEG) is a non-invasive method of measuring neural activity but the hippocampus and amygdala are difficult to measure with MEG because of their deep localization. Here, the authors show with simultaneous MEG and invasive recordings that hippocampus and amygdala activity can be retrieved from the surface.

Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase, and displays pronounced activity against pathogenic fungi of the order Mucorales.

Here, Chemnitz et al. report experimental evidence for hybrid solitons – a type of solitary wave, which emerges as a result of a strong non-instantaneous nonlinear response in CS₂-filled liquid-core optical fibres, demonstrating efficient soliton-driven supercontinuum generation.

Ibrutinib, a Bruton tyrosine kinase inhibitor, provides effective treatment for chronic lymphocytic leukemia (CLL). Here, the authors describe time-dependent molecular changes to malignant cells and to the immune system in patients undergoing ibrutinib therapy, with can be used for therapy monitoring.

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

The continue advancement in accelerators instrumentation is placing increasingly stringent requirements on the measure of beam sizes. The paper discusses the development of an electron beam diagnostics for measuring sub-micron beam sizes, opening the window to sub-micrometre resolution.

Active rotating particles were shown to undergo a phase separation through numerical simulations. Here the authors provide an experimental realization of this phenomenon by presenting an ensemble of 3D-printed robots that rotate in different directions and interact with each other.