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Showing 1–4 of 4 results
Advanced filters: Author: Christina Glytsou Clear advanced filters

  • Restriction of dietary valine reduces growth of T cell acute lymphoblastic leukaemia through altered valine tRNA biogenesis and reduced translation of mRNAs that encode subunits of mitochondrial complex I.

    • Palaniraja Thandapani
    • Andreas Kloetgen
    • Iannis Aifantis
    Research
    Nature
    Volume: 601, P: 428-433

  • Patients with acute myeloid leukaemia are often unable to tolerate intensive chemotherapy, and the outcomes of these patients have improved considerably following the availability of regimens containing the BH3 mimetic venetoclax. Nonetheless, not all of these patients will respond to venetoclax, and virtually all will ultimately develop resistance, indicating a need for novel treatment strategies targeting this pathway. In this Review, the authors describe the development of BCL-2 inhibitors, discuss mechanisms of resistance and summarize ongoing research efforts aimed at optimizing the therapeutic benefit of these agents.

    • Antonino Glaviano
    • Ellen Weisberg
    • Alan P. Kumar
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 847-868

  • Mitochondrial networks are dynamically remodelled via fusion, fission and ultrastructural changes to mitochondrial membranes. These mitochondrial membrane dynamics are tightly coupled to cell function, with morphological changes to mitochondria accompanying a multitude of processes as diverse as cell pluripotency, division, differentiation, senescence and death. Accordingly, disturbed dynamics of mitochondrial membranes are linked to severe human disorders.

    • Marta Giacomello
    • Aswin Pyakurel
    • Luca Scorrano
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 204-224