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Showing 1–3 of 3 results
Advanced filters: Author: Christine Tesar Clear advanced filters

  • A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.

    • Chien-Wen Chen
    • David Papadopoli
    • Maria Hatzoglou
    ResearchOpen Access
    Nature
    Volume: 641, P: 1319-1328

  • The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bound inhibitors, which is of interest for further structure-based drug design efforts.

    • Jerzy Osipiuk
    • Saara-Anne Azizi
    • Andrzej Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Understanding mechanisms of PLpro substrate selectivity offers new ways to decouple substrate activities and will inform new therapeutic strategies. Here, the authors use multi-disciplinary approaches to uncover how PLpro from SARS-CoV-2 can discriminate between different substrates.

    • Pawel M. Wydorski
    • Jerzy Osipiuk
    • Lukasz A. Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18