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Showing 1–19 of 19 results
Advanced filters: Author: Christoph Scheiermann Clear advanced filters

  • Exhausted CD8+ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

    • Yingxi Xu
    • Yangtao Shangguan
    • Ping-Chih Ho
    Research
    Nature
    P: 1-10

  • In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (before 15:00 h) experienced longer progression-free survival compared with those receiving late time-of-day infusions.

    • Zhe Huang
    • Liang Zeng
    • Yongchang Zhang
    Research
    Nature Medicine
    P: 1-8

  • Neurotrophic factor Nerve Growth Factor (NGF) is involved in bladder physiopathology. Here the authors report that mast-cell derived NGF sustains the pro-tumoral functions of ILC2s in bladder cancer (BC), showing that selective targeting of the NGF receptor TrkA improves survival and response to immune checkpoint blockade in BC models.

    • Maryline Falquet
    • Hajar El Ahanidi
    • Camilla Jandus
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Scheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin lymphatics in mice and humans, with a peak migration to the lymph nodes during the rest phase.

    • Stephan J. Holtkamp
    • Louise M. Ince
    • Christoph Scheiermann
    ResearchOpen Access
    Nature Immunology
    Volume: 22, P: 1375-1381

  • Plasmacytoid dendritic cells monitor the bone marrow for apoptotic megakaryocytes (MKs) and deliver IFNα to the MK niche, triggering local on-demand proliferation and maturation of MK progenitors.

    • Florian Gaertner
    • Hellen Ishikawa-Ankerhold
    • Steffen Massberg
    ResearchOpen Access
    Nature
    Volume: 631, P: 645-653

  • Here, the authors discuss recent evidence indicating that components of the immune system are under the control of circadian rhythms. The circadian oscillations of immune mediators may allow the host to anticipate threats more efficiently but may also contribute to circadian exacerbations of chronic diseases. In addition, these circadian rhythms should be considered in the design of preclinical animal models, when harvesting human tissue samples and in vaccine administration.

    • Christoph Scheiermann
    • Yuya Kunisaki
    • Paul S. Frenette
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 190-198

  • Rhythmic trafficking of dendritic cells to the tumour draining lymph node governs a circadian response of tumour-antigen-specific CD8+ T cells that is dependent on the circadian expression of the co-stimulatory molecule CD80.

    • Chen Wang
    • Coline Barnoud
    • Christoph Scheiermann
    ResearchOpen Access
    Nature
    Volume: 614, P: 136-143

  • Circadian rhythms have been shown to influence immune responses, but it is unclear whether this influences responses to vaccines. Here the authors show that dendritic cells migrate in a circadian rhythm meaning that interactions with T cells are altered leading to differential vaccine responses.

    • Louise Madeleine Ince
    • Coline Barnoud
    • Christoph Scheiermann
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Maternal circadian rhythms influence the health of infants. Cui, Xu and colleagues find that disruption of maternal rhythms impairs neonatal immune cell function and aggravates neonatal inflammatory disorders, which can be rescued by the administration of docosahexaenoic acid (a metabolite found in breast milk).

    • Xia Li
    • Markus Sperandio
    • Christoph Scheiermann
    News & Views
    Nature Metabolism
    Volume: 6, P: 787-788

  • Immunofluorescence imaging and computational modelling are used to study the spatial distribution of different cell types within the haematopoietic stem cell (HSC) niche; findings show that quiescent HSCs associate specifically with small arterioles that are preferentially found in the endosteal bone marrow and are essential in maintaining this quiescence.

    • Yuya Kunisaki
    • Ingmar Bruns
    • Paul S. Frenette
    Research
    Nature
    Volume: 502, P: 637-643

  • This Review considers the importance of the core circadian clock for regulating both innate and adaptive immune cell responses. The authors consider the implications for vaccination and other clinical strategies, highlighting the emerging field of chrono-immunotherapy.

    • Christoph Scheiermann
    • Julie Gibbs
    • Andrew Loudon
    Reviews
    Nature Reviews Immunology
    Volume: 18, P: 423-437

  • Many chemotherapy drugs cause sensory nerve damage as well as long-lasting damage to hematopoietic regeneration in the bone marrow. Paul Frenette and his colleagues show that this hematopoietic damage is caused by injury to bone marrow sympathetic nerve fibers, disrupting the hematopoietic stem cell niche. These findings point to the potential of neuroprotective agents in preserving hematopoietic function in chemotherapy-treated patients with cancer.

    • Daniel Lucas
    • Christoph Scheiermann
    • Paul S Frenette
    Research
    Nature Medicine
    Volume: 19, P: 695-703

  • Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.

    • Dachuan Zhang
    • Grace Chen
    • Paul S. Frenette
    Research
    Nature
    Volume: 525, P: 528-532

  • Two papers in this issue, by Bruns et al. and Zhao et al., show that megakaryocytes constitute a niche for hematopoietic stem cells in the mouse bone marrow and produce factors that regulate hematopoietic stem cell quiescence and proliferation.

    • Ingmar Bruns
    • Daniel Lucas
    • Paul S Frenette
    Research
    Nature Medicine
    Volume: 20, P: 1315-1320