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Showing 1–10 of 10 results
Advanced filters: Author: Christopher Chase Bolt Clear advanced filters

  • A highly selective covalent peptide inhibitor of the peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is used to show that Pin1 cooperates with mutant KRAS to promote pancreatic ductal adenocarcinoma (PDAC) transformation.

    • Benika J. Pinch
    • Zainab M. Doctor
    • Nathanael S. Gray
    Research
    Nature Chemical Biology
    Volume: 16, P: 979-987

  • A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

    • Erik L. Bao
    • Satish K. Nandakumar
    • Vijay G. Sankaran
    Research
    Nature
    Volume: 586, P: 769-775

  • A multi-ancestry genome-wide association study for age at menarche followed by fine mapping and downstream analysis implicates 665 pubertal timing genes, such as the G-protein-coupled receptor 83 (GPR83) and other genes expressed in the ovaries involved in the DNA damage response.

    • Katherine A. Kentistou
    • Lena R. Kaisinger
    • Ken K. Ong
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1397-1411

  • Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanistic framework to understand and unify the molecular origins of human mesomelic dysplasia associated with 2q31.

    • Christopher Chase Bolt
    • Lucille Lopez-Delisle
    • Denis Duboule
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transverse-tubule organization, and mitochondria

    • Yuxuan Guo
    • Blake D. Jardin
    • William T. Pu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new neighboring enhancers located in the recipient TAD.

    • Christopher Chase Bolt
    • Lucille Lopez-Delisle
    • Denis Duboule
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15