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Showing 101–150 of 192 results

Advanced filters: Author: Christopher J. Patterson Clear advanced filters

A second generation human haplotype map of over 3.1 million SNPs

A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

Kelly A. Frazer (Principal Investigator)
Dennis G. Ballinger
John Stewart
Research18 Oct 2007
Nature

Volume: 449, P: 851-861
Genomic data in the All of Us Research Program

A study describes the release of clinical-grade whole-genome sequence data for 245,388 diverse participants by the All of Us Research Program and characterizes the properties of the dataset.

Alexander G. Bick
Ginger A. Metcalf
Joshua C. Denny
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 340-346
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

A risk haplotype for type 2 diabetes is identified with four amino acid substitutions in SLC16A11, which is present at ∼50% frequency in Native American samples and ∼10% in east Asian samples, but is rare in European and African samples; SLC16A11 may alter hepatic lipid metabolism, causing an increase in triacylglycerol levels.

Amy L. Williams
Suzanne B. R. Jacobs
Teresa Tusié-Luna
Research25 Dec 2013
Nature

Volume: 506, P: 97-101
Erratum: The Beaker phenomenon and the genomic transformation of northwest Europe

Iñigo Olalde
Selina Brace
David Reich
Amendments and Corrections22 Mar 2018
Nature

Volume: 555, P: 543
Early adverse physiological event detection using commercial wearables: challenges and opportunities

Jesse Phipps
Bryant Passage
Roozbeh Jafari
ResearchOpen Access23 May 2024
npj Digital Medicine

Volume: 7, P: 1-13
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

Christopher E Lowe
Jason D Cooper
John A Todd
Research05 Aug 2007
Nature Genetics

Volume: 39, P: 1074-1082
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty

Timothy E. Yen
John C. Allen
Madan M. Kwatra
ResearchOpen Access05 Feb 2016
Scientific Reports

Volume: 6, P: 1-7
Supervised dimensionality reduction for big data

Biomedical measurements usually generate high-dimensional data where individual samples are classified in several categories. Vogelstein et al. propose a supervised dimensionality reduction method which estimates the low-dimensional data projection for classification and prediction in big datasets.

Joshua T. Vogelstein
Eric W. Bridgeford
Mauro Maggioni
ResearchOpen Access17 May 2021
Nature Communications

Volume: 12, P: 1-9
Genome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh
Claire M Wade
Eric S. Lander
Research08 Dec 2005
Nature

Volume: 438, P: 803-819
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Anthropogenic plutonium-244 in the environment: Insights into plutonium’s longest-lived isotope

Christopher R. Armstrong
Heather A. Brant
James R. Cadieux
ResearchOpen Access22 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Intracellular dynamics of hippocampal place cells during virtual navigation

As we navigate, spatial information is encoded in both rate and temporal codes by place cells located in the hippocampus. To investigate the origin of these codes, the intracellular dynamics of place cells are now measured in vivo in awake mice navigating a virtual-reality environment. Three subthreshold signatures of place fields are identified that underlie the primary features of place-cell rate and temporal codes.

Christopher D. Harvey
Forrest Collman
David W. Tank
Research15 Oct 2009
Nature

Volume: 461, P: 941-946
Pre-exposure immunohematologic features of heart failure associate with COVID-19 mortality

David A. Zidar
Brigid M. Wilson
Jarrod E. Dalton
ResearchOpen Access21 Nov 2024
npj Cardiovascular Health

Volume: 1, P: 1-8
Observation of the rare B_s⁰ →µ⁺µ⁻ decay from the combined analysis of CMS and LHCb data

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

V. Khachatryan
A.M. Sirunyan
E. Pesen
ResearchOpen Access13 May 2015
Nature

Volume: 522, P: 68-72
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
Enhanced physical and cognitive performance in active duty Airmen: evidence from a randomized multimodal physical fitness and nutritional intervention

Christopher E. Zwilling
Adam Strang
Aron K. Barbey
ResearchOpen Access19 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders

Richard J L Anney
Elaine M Kenny
Louise Gallagher
Research27 Apr 2011
European Journal of Human Genetics

Volume: 19, P: 1082-1089
Multiple regions within 8q24 independently affect risk for prostate cancer

Christopher A Haiman
Nick Patterson
David Reich
Research01 Apr 2007
Nature Genetics

Volume: 39, P: 638-644
RETRACTED ARTICLE: A Tunguska sized airburst destroyed Tall el-Hammam a Middle Bronze Age city in the Jordan Valley near the Dead Sea

Ted E. Bunch
Malcolm A. LeCompte
Phillip J. Silvia
ResearchOpen Access20 Sept 2021
Scientific Reports

Volume: 11, P: 1-64
Toil enables reproducible, open source, big biomedical data analyses

John Vivian
Arjun Arkal Rao
Benedict Paten
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 314-316
Leveraging population admixture to characterize the heritability of complex traits

Noah Zaitlen, Alkes Price and colleagues report a new approach to estimate the narrow-sense heritability of complex traits from unrelated individuals in a recently admixed population. They apply this approach to estimate the heritability for 13 quantitative or case-control phenotypes in 21,497 African-American individuals and suggest the inflation of family-based h² estimates.

Noah Zaitlen
Bogdan Pasaniuc
Alkes L Price
Research10 Nov 2014
Nature Genetics

Volume: 46, P: 1356-1362
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus

Analysis of the FGF14-SCA27B repeat locus identifies a common 5′-flanking insertion that represents the major allele, is present exclusively on nonpathogenic alleles, enhances repeat stability and increases chromatin accessibility.

David Pellerin
Giulia F. Del Gobbo
Matt C. Danzi
Research27 Jun 2024
Nature Genetics

Volume: 56, P: 1366-1370
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

Whole-genome sequencing identifies a novel germline variant in the oncogene MITF, which is associated with the development of melanoma.

Satoru Yokoyama
Susan L. Woods
Kevin M. Brown
ResearchOpen Access13 Nov 2011
Nature

Volume: 480, P: 99-103
Polycyclic aromatic hydrocarbon exposures of children in low-income families¹

JANE C CHUANG
PATRICK J CALLAHAN
NANCY K WILSON
Research28 Jul 1999
Journal of Exposure Science & Environmental Epidemiology

Volume: 9, P: 85-98
The East Bay Diesel Exposure Project: a biomonitoring study of parents and their children in heavily impacted communities

Daniel Sultana
Duyen Kauffman
Sara Hoover
ResearchOpen Access15 Dec 2023
Journal of Exposure Science & Environmental Epidemiology

Volume: 34, P: 827-835
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

Joseph R. Patterson
Joseph Kochmanski
Caryl E. Sortwell
ResearchOpen Access03 Jan 2024
npj Parkinson's Disease

Volume: 10, P: 1-17
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

Joseph R. Patterson
Warren D. Hirst
Caryl E. Sortwell
ResearchOpen Access24 May 2022
npj Parkinson's Disease

Volume: 8, P: 1-14
Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biology

Alexander S Krupnick
Xue Lin
Daniel Kreisel
Protocols18 Dec 2008
Nature Protocols

Volume: 4, P: 86-93
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
A systematic review to identify assessment instruments for social isolation or loneliness in adults with heart failure

Scott William
Julee McDonagh
Caleb Ferguson
ResearchOpen Access07 Mar 2025
npj Cardiovascular Health

Volume: 2, P: 1-17
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Efficient energy transfer and photoluminescence enhancement in 2D MoS₂/bulk InSe van der Waals heterostructures

Michael A. Altvater
Christopher E. Stevens
Nicholas R. Glavin
ResearchOpen Access13 Apr 2025
npj 2D Materials and Applications

Volume: 9, P: 1-8
Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms

Christopher Selleck
Marcelo Monteiro Pedroso
Gerhard Schenk
ResearchOpen Access30 Jul 2020
Scientific Reports

Volume: 10, P: 1-14
Decline of coastal apex shark populations over the past half century

George Roff et al. report a 74–92% decline in the catch per unit effort and concurrent declines in body size of large coastal apex sharks near Australia over the past five decades. This study highlights shifting baselines of shark populations in coastal shark assemblages, and indicates that shark populations are highly vulnerable to exploitation.

George Roff
Christopher J. Brown
Peter J. Mumby
ResearchOpen Access13 Dec 2018
Communications Biology

Volume: 1, P: 1-11
Global imprint of climate change on marine life

Research that combines all available studies of biological responses to regional and global climate change shows that 81–83% of all observations were consistent with the expected impacts of climate change. These findings were replicated across taxa and oceanic basins.

Elvira S. Poloczanska
Christopher J. Brown
Anthony J. Richardson
Research04 Aug 2013
Nature Climate Change

Volume: 3, P: 919-925
Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI

This protocol describes the isolation of gas-filled protein nanostructures, called gas vesicles, their functionalization with moieties for targeting and fluorescence, and how to use them as contrast agents for ultrasound and MRI.

Anupama Lakshmanan
George J Lu
Mikhail G Shapiro
Protocols07 Sept 2017
Nature Protocols

Volume: 12, P: 2050-2080
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Background pressure effects on MeV protons accelerated via relativistically intense laser-plasma interactions

Joseph Snyder
John Morrison
William Roquemore
ResearchOpen Access26 Oct 2020
Scientific Reports

Volume: 10, P: 1-7
A holistic approach to performance prediction in collegiate athletics: player, team, and conference perspectives

Christopher B. Taber
Srishti Sharma
Tolga Kaya
ResearchOpen Access12 Jan 2024
Scientific Reports

Volume: 14, P: 1-10
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Agricultural fungicides inadvertently influence the fitness of Colorado potato beetles, Leptinotarsa decemlineata, and their susceptibility to insecticides

Justin Clements
Sean Schoville
Russell L. Groves
ResearchOpen Access05 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor

Christopher L. Averill
Lynnette A. Averill
Chadi G. Abdallah
ResearchOpen Access17 Jun 2024
NPP—Digital Psychiatry and Neuroscience

Volume: 2, P: 1-8
Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

Self-hybridized exciton–polaritons are shown to enable sub-bandgap absorption and emission in 2D perovskites. The energy absorbed by the perovskites are also found to transfer to few-layer graphene in a heterostructure.

Surendra B. Anantharaman
Jason Lynch
Deep Jariwala
ResearchOpen Access01 Jan 2024
Light: Science & Applications

Volume: 13, P: 1-10
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

John A Todd
Neil M Walker
David G Clayton
Research06 Jun 2007
Nature Genetics

Volume: 39, P: 857-864
Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression

Lina Gliaudelytė
Steven P. Rushton
Christopher M. Morris
ResearchOpen Access20 Mar 2025
Translational Psychiatry

Volume: 15, P: 1-11
Quasi-periodic events in crystal plasticity and the self-organized avalanche oscillator

A crystalline material is investigated that responds to a slowly increasing external stress by exhibiting impulsive ‘avalanche’ behaviour as well as smooth stress release that is approximately as slow as the external stress rate; unusual oscillatory behaviour in the avalanche time series is reported.

Stefanos Papanikolaou
Dennis M. Dimiduk
Stefano Zapperi
Research24 Oct 2012
Nature

Volume: 490, P: 517-521
Long COVID diagnostic with differentiation from chronic lyme disease using machine learning and cytokine hubs

Bruce K. Patterson
Jose Guevara-Coto
Joseph A. Bellanti
ResearchOpen Access26 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Characterizing advanced breast cancer heterogeneity and treatment resistance through serial biopsies and comprehensive analytics

Allen Li
Jamie M. Keck
Zahi I. Mitri
ResearchOpen Access26 Mar 2021
npj Precision Oncology

Volume: 5, P: 1-12

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