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Showing 1–9 of 9 results
Advanced filters: Author: Chrysothemis C. Brown Clear advanced filters
  • Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomeninges.

    • Jan Remsik
    • Xinran Tong
    • Adrienne Boire
    ResearchOpen Access
    Nature
    Volume: 643, P: 1087-1096
  • Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA patients to provide a molecular immune landscape for PsA.

    • Frank Penkava
    • Martin Del Castillo Velasco-Herrera
    • M. Hussein Al-Mossawi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11
  • Single-cell transcriptomic and epigenetic analysis has enabled the identification of Thetis cells, a class of RORγt+ antigen-presenting cells with a key role in the differentiation of commensal microbiota-induced peripheral regulatory T cells.

    • Blossom Akagbosu
    • Zakieh Tayyebi
    • Chrysothemis C. Brown
    ResearchOpen Access
    Nature
    Volume: 610, P: 752-760
  • Can a patient's genotype provide insight into the mechanistic basis of autoimmune disease? A study integrating epigenetic data with finely mapped disease-associated variants sheds light on how noncoding variants might alter gene expression within specific immune cells, and hints at new possibilities for individualizing treatment of autoimmune rheumatic disorders.

    • Chrysothemis C. Brown
    • Lucy R. Wedderburn
    News & Views
    Nature Reviews Rheumatology
    Volume: 11, P: 131-132
  • Recent studies have highlighted the diversity and distinct nature of regulatory T cells in the intestine, where they must balance a multitude of signals from the microbiota and the diet to ensure immune homeostasis. But questions and controversies remain over their origins and regulation, as discussed here.

    • Deepshika Ramanan
    • Alvin Pratama
    • Christophe Benoist
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 749-762