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Advanced filters: Author: Chu-Ting Chang Clear advanced filters

CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling

Metabotropic glutamate receptor 6 (mGlu6) mediates visual signaling in the retina. Here, authors report cryo-EM structures of mGlu6, providing structural insight into the asymmetric intermediate state and congenital stationary night blindness.

Seo Young Lee
Chu-Ting Chang
Hyung Ho Lee
ResearchOpen Access09 Mar 2026
Nature Communications

P: 1-12
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

Li et al. identify dynorphin as an endogenous ligand for orphan receptor GPR139 introducing it as a non-canonical member of the opioid receptor family that triggers excitatory signaling to balance the inhibitory effects of opioids.

Xiaona Li
Nathan D. Winters
Kirill A. Martemyanov
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy

Chu-Ting Liang
Yu-Shan Lin
Ta-Hsien Lin
ResearchOpen Access08 Jan 2018
Scientific Reports

Volume: 8, P: 1-12

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CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy

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