Nature Search

Author Correction: Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Dario F. De Jesus
Zijie Zhang
Rohit N. Kulkarni
Amendments and Corrections17 Nov 2025
Nature Cell Biology

Volume: 28, P: 208
Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

Cheng-Wei Ju
Han Li
Chuan He
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

Haoxuan Li
Guanqun Wang
Chuan He
Amendments and Corrections21 Jan 2025
Nature Plants

Volume: 11, P: 376
The clinical characteristics of anemia in native adults living at different altitudes of the Tibetan Plateau

Jie Fang
Ran Li
Kai Xue
ResearchOpen Access24 Feb 2023
Scientific Reports

Volume: 13, P: 1-6
Small-molecule-catalysed deamination enables transcriptome-wide profiling of N⁶-methyladenosine in RNA

Nucleobase deamination can be used to map N⁶-methyladenosine in RNA, but existing deamination methods are harsh, limiting applications. Now a method for the N-nitrosation of RNA based on organocatalyst and Lewis acid co-catalysis has been shown to enable sensitive N⁶-methyladenosine mapping with minimal background noise and high detection efficiency.

Pingluan Wang
Chang Ye
Chuan He
Research17 Apr 2025
Nature Chemistry

Volume: 17, P: 1042-1052
Validation and refinement of the 2022 European LeukaemiaNet genetic risk classification of acute myeloid leukaemia patients receiving allogeneic haematopoietic cell transplantation

Weihao Chen
Lieguang Chen
Yanmin Zhao
Research28 Oct 2024
Leukemia

Volume: 38, P: 2712-2716
Impaired histone inheritance promotes tumor progression

Here the authors show disturbing parental histone inheritance in cancer cells drives tumor progression by reprogramming the epigenetic profile and conferring fitness advantages to some of the newly emerged subclones.

Congcong Tian
Jiaqi Zhou
Haiyun Gan
ResearchOpen Access10 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

The comprehensive and quantitative mapping of pseudouridine (Ψ) sites across four plant species provides critical resources for plant Ψ research, and reveals multilayered translation regulation through rRNA, tRNA and mRNA pseudouridylation in plants.

Haoxuan Li
Guanqun Wang
Chuan He
Research09 Jan 2025
Nature Plants

Volume: 11, P: 234-247
Quantitative profiling of m⁶A at single base resolution across the life cycle of rice and Arabidopsis

The authors profile single-base resolution maps at each modified mRNA m⁶A site in rice and Arabidopsis, and uncover a suppression-activation dual regulation model in shaping m⁶A distribution patterns in different species.

Guanqun Wang
Haoxuan Li
Chuan He
ResearchOpen Access07 Jun 2024
Nature Communications

Volume: 15, P: 1-14
Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

De Jesus et al. describe the redox-mediated regulation of m⁶A writer methyltransferase 3, which blunts innate immune responses by modification of RNA sensor and editor component mRNAs during the onset of type 1 diabetes in β-cells.

Dario F. De Jesus
Zijie Zhang
Rohit N. Kulkarni
Research26 Feb 2024
Nature Cell Biology

Volume: 26, P: 421-437
Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

Colorectal cancer is discriminated by measuring cell-free RNA methylation in plasma.

Cheng-Wei Ju
Ruitu Lyu
Chuan He
Research08 Jul 2025
Nature Biotechnology

P: 1-7
Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections27 Aug 2020
Nature Cell Biology

Volume: 22, P: 1288
Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections07 Jun 2018
Nature Cell Biology

Volume: 20, P: 1098
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.

Quanjiang Ji
Peter J. Chen
Chuan He
ResearchOpen Access18 Mar 2016
Nature Communications

Volume: 7, P: 1-11
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

X-ray crystallographic analysis of thymine DNA glycosylase (TDG) in complex with DNA containing 5-carboxylcytosine (5caC) analogs reveals that 5caC is a preferred substrate of TDG, providing support for a 5-methylcytosine demethylation pathway involving 5-methylcytosine oxidation and removal by base-excision repair glycosylases.

Liang Zhang
Xingyu Lu
Chuan He
Research12 Feb 2012
Nature Chemical Biology

Volume: 8, P: 328-330
Outcomes of acute myeloid leukemia with KMT2A (MLL) rearrangement: a multicenter study of TROPHY group

Ruoxuan Zhang
Huihong Huang
Yang Cao
ResearchOpen Access02 May 2025
Blood Cancer Journal

Volume: 15, P: 1-10
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Copper is a transition metal ion essential for the regulation of cellular oxidative stress and ATP production. Now, the inhibition of copper-trafficking proteins by a small molecule has been shown to significantly reduce proliferation of cancer cells. The results indicate that copper-trafficking proteins could represent new anti-tumour therapeutic targets.

Jing Wang
Cheng Luo
Chuan He
Research09 Nov 2015
Nature Chemistry

Volume: 7, P: 968-979
Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huang et al. identify IGF2BPs as an additional class of N⁶-methyladenosine (m⁶A) reader proteins. They find that IGF2BPs selectively bind to m⁶A-containing mRNAs and promote their stability.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research23 Feb 2018
Nature Cell Biology

Volume: 20, P: 285-295
Effect of therapeutic erythrocytapheresis on outcomes and renal benefit in patients with high-altitude polycythemia: a real-world study

Yan Ouyang
Yinyin Zhang
Kai Qing
ResearchOpen Access23 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
m⁶A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes

m⁶A mRNA methylation regulates several cellular processes, including cancer progression and stem cell maintenance. Here, De Jesus and colleagues demonstrate that the m⁶A landscape segregates human type 2 diabetic islets from controls and that m⁶A is fundamental for human β-cell biology.

Dario F. De Jesus
Zijie Zhang
Rohit N. Kulkarni
Research29 Jul 2019
Nature Metabolism

Volume: 1, P: 765-774
Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m⁶A modifications co-transcriptionally.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research13 Mar 2019
Nature

Volume: 567, P: 414-419
Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale

Chemical modification of 5fC allows its enrichment and genome-wide profiling at single-nucleotide resolution.

Bo Xia
Dali Han
Chengqi Yi
Research07 Sept 2015
Nature Methods

Volume: 12, P: 1047-1050
MRD positivity was the poor prognostic factor for adverse-risk AML patients with allogeneic hematopoietic stem cell transplantation: a multicenter TROPHY study

Yang Cao
Wenxuan Huo
Xiaodong Mo
CorrespondenceOpen Access17 Jan 2024
Blood Cancer Journal

Volume: 14, P: 1-6
Allogeneic hematopoietic stem cell transplantation for adult acute myeloid leukemia patients with nucleoporin 98 (NUP98) gene rearrangements: a real-world study in China

Yang Cao
Chunli Zhang
Xiaoxia Hu
Correspondence20 Sept 2023
Bone Marrow Transplantation

Volume: 58, P: 1413-1415

Search

Author Correction: Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution

Author Correction: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

The clinical characteristics of anemia in native adults living at different altitudes of the Tibetan Plateau

Small-molecule-catalysed deamination enables transcriptome-wide profiling of N⁶-methyladenosine in RNA

Validation and refinement of the 2022 European LeukaemiaNet genetic risk classification of acute myeloid leukaemia patients receiving allogeneic haematopoietic cell transplantation

Impaired histone inheritance promotes tumor progression

Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation

Quantitative profiling of m⁶A at single base resolution across the life cycle of rice and Arabidopsis

Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples

Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

Outcomes of acute myeloid leukemia with KMT2A (MLL) rearrangement: a multicenter study of TROPHY group

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Effect of therapeutic erythrocytapheresis on outcomes and renal benefit in patients with high-altitude polycythemia: a real-world study

m⁶A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes

Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale

MRD positivity was the poor prognostic factor for adverse-risk AML patients with allogeneic hematopoietic stem cell transplantation: a multicenter TROPHY study

Allogeneic hematopoietic stem cell transplantation for adult acute myeloid leukemia patients with nucleoporin 98 (NUP98) gene rearrangements: a real-world study in China

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