Nature Search

In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy

An injectable pH-sensitive nanoadjuvant is shown to induce effective pyroptosis of tumours, which, combined with the in situ photoactivable release of TLR agonists, generates a strong vaccine-like response to eradicate the tumour.

Binlong Chen
Fangjie Wan
Yiguang Wang
Research03 Mar 2026
Nature Materials

P: 1-12
Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Chuanhui Han
Zhida Liu
Yang-Xin Fu
Amendments and Corrections16 Sept 2020
Nature Immunology

Volume: 21, P: 1470
A machine learning-based short-term forecasting method for heavy fog in Anhui Province of China

Yan Sun
Chuanhui Wang
Xiang Wang
ResearchOpen Access13 Jan 2026
Scientific Reports

Volume: 16, P: 1-14
Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration

Activation of the stimulator of interferon genes (STING) can induce immunity in various cancer therapies, but delivery of STING agonists to tumours is challenging. Now a metal-based polymeric nanoparticle delivers STING agonists to tumours upon disruption of endothelial cells in tumour vasculature and targets tumour-associated macrophages, eliciting anti-tumour immune response in hard-to-treat cancer models.

Kaiting Yang
Wenbo Han
Ralph R. Weichselbaum
Research27 Oct 2022
Nature Nanotechnology

Volume: 17, P: 1322-1331
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Therapeutic irradiation can trigger DNA-sensing pathways and trigger antitumor immunity. Fu and colleagues demonstrate that tumors can co-opt intrinsic apoptotic pathways to avoid immunogenic cell death following irradiation.

Chuanhui Han
Zhida Liu
Yang-Xin Fu
Research30 Mar 2020
Nature Immunology

Volume: 21, P: 546-554
Host-guest-induced electronic state triggers two-electron oxygen reduction electrocatalysis

Dynamic bonds offer unique advantages of adaptability and selectivity, yet, supramolecular electrocatalysts specifically tailored for 2e⁻ pathway remain unexplored. Here, the authors report a host-guest strategy that employs dynamic bonds to adjust electronic states through dual-channel regulation.

Hongni Chen
Chao Wang
Xiaojing Long
ResearchOpen Access25 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells

A bispecific antibody targeting the T-cell co-receptor CD3ε and the immune checkpoint programmed-death ligand 1 on dendritic cells rejuvenates tumour-specific CD8 T cells, leading to durable antitumour responses in murine models of cancer.

Longchao Liu
Jiahui Chen
Yang-Xin Fu
Research01 Nov 2021
Nature Biomedical Engineering

Volume: 5, P: 1261-1273
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.

Xiaoguang Li
Zhida Liu
Yang-Xin Fu
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Data-driven computational prediction and experimental realization of exotic perovskite-related polar magnets

Yifeng Han
Meixia Wu
Man-Rong Li
ResearchOpen Access09 Dec 2020
npj Quantum Materials

Volume: 5, P: 1-9
Targeting innate sensing in the tumor microenvironment to improve immunotherapy

Zhida Liu
Chuanhui Han
Yang-Xin Fu
Reviews16 Dec 2019
Cellular & Molecular Immunology

Volume: 17, P: 13-26
Small molecular drugs reshape tumor microenvironment to synergize with immunotherapy

Chuanhui Han
Anli Zhang
Yang-Xin Fu
Reviews07 Dec 2020
Oncogene

Volume: 40, P: 885-898

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