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Inhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an antifungal strategy

Drug resistance and limited antifungal therapies necessitate innovative strategies. Using cis-fumaramidmycin-derived probes, the authors reveal inhibition of the Mrt4- rRNA interaction as a promising vulnerability for combating drug resistant fungi.

Hongxuan Cao
Jie Tu
Yanliang Ren
ResearchOpen Access04 Mar 2026
Nature Communications

Volume: 17, P: 1-18

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Inhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an antifungal strategy

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