Nature Search

Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency

IL-27RA–IL-27 has a critical role in the immunity to EBV, and this defence is hijacked by Epstein–Barr virus to promote the expansion of infected transformed B cells

Emmanuel Martin
Sarah Winter
Sylvain Latour
Research20 Mar 2024
Nature

Volume: 628, P: 620-629
Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Disparities in risk and outcomes of pediatric acute lymphoblastic leukemia (ALL) are apparent between different ancestries. Here the authors identify genetic variants with African ancestry-specific risks for developing pediatric B-cell ALL that are also linked to greater 5-year mortality risk.

Cindy Im
Andrew R. Raduski
Logan G. Spector
ResearchOpen Access22 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Molecular characterization of the Arabidopsis floral homeotic gene APETALA1

M. Alejandra Mandel
Cindy Gustafson-Brown
Martin F. Yanofsky
Research19 Nov 1992
Nature

Volume: 360, P: 273-277
Treatment, toxicity, and mortality after subsequent breast cancer in female survivors of childhood cancer

Children receiving chest radiotherapy for childhood cancer have a higher risk of developing breast cancer later in life. Here, using the data from the Childhood Cancer Survivor Study, the authors investigate the treatment and survival outcomes of breast cancer patients who previously survived childhood cancer finding them to receive altered treatment and having increased mortality.

Cindy Im
Hasibul Hasan
Lucie M. Turcotte
ResearchOpen Access31 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Reza Asadollahi
Aisha Ahmad
Noa Lipstein
ResearchOpen Access22 Oct 2025
Nature Genetics

Volume: 57, P: 2691-2704
Cytotoxic T cells that escape exhaustion

T cells of the immune system mount antiviral responses, but if a response fails, a chronic viral infection can develop. It now seems that a T-cell subset in lymphoid immune tissues can control chronic infection. See Letters p.412 & p.417

Cindy S. Ma
Stuart G. Tangye
News & Views24 Aug 2016
Nature

Volume: 537, P: 312-314
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 cancer types on a single clinical ICB trial and identify tumour microenvironment features associated with response.

S. Y. Cindy Yang
Scott C. Lien
Trevor J. Pugh
ResearchOpen Access26 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 294-305
INTRAVENTRICULAR HEMORRHAGE (IVH) & VITAMIN E (VE) IN VERY LOW BIRTH WEIGHT INFANTS: EFFICACY OF EARLY IM ADMINISTRATION

Michael E Speer
Cindy Blifeld
Helen M Hittner
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 383
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification

This Registered Report presents the results of the Long-read RNA-Seq Genome Annotation Assessment Project, which is a community effort for benchmarking long-read methods for transcriptome analyses, including transcript isoform detection, quantification and de novo transcript detection.

Francisco J. Pardo-Palacios
Dingjie Wang
Angela N. Brooks
ResearchOpen Access07 Jun 2024
Nature Methods

Volume: 21, P: 1349-1363
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

The evolutionary history of pigs in Africa is unclear. Here, the authors examine 67 whole genomes, finding incomplete speciation between bushpigs and red river hogs as well as evidence suggesting that humans brought bushpigs to Madagascar 1000-5000 years ago.

Renzo F. Balboa
Laura D. Bertola
Rasmus Heller
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands

Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.

Florian Haller
Matthias Bieg
Abbas Agaimy
ResearchOpen Access21 Jan 2019
Nature Communications

Volume: 10, P: 1-13
Late preterm antenatal steroid use and infant outcomes in a single center

Mitzi Go
Madison Wahl
Cindy T. McEvoy
Research18 Mar 2024
Journal of Perinatology

Volume: 44, P: 1009-1013
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a cohort of post-treatment controllers.

Luis M. Molinos-Albert
Valérie Lorin
Laetitia Laine
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

Julia Parrish-Novak
Stacey R. Dillon
Don Foster
Research02 Nov 2000
Nature

Volume: 408, P: 57-63
Fatty acid transport protein 2 reprograms neutrophils in cancer

The lipid transporter FATP2 reprograms neutrophils to polymorphonuclear myeloid-derived suppressor cells by mediating the uptake of arachidonic acid and promoting the synthesis of prostaglandin E₂.

Filippo Veglia
Vladimir A. Tyurin
Dmitry I. Gabrilovich
Research17 Apr 2019
Nature

Volume: 569, P: 73-78
Transplantation of human microbiota into conventional mice durably reshapes the gut microbiota

Laura Wrzosek
Dragos Ciocan
Anne-Marie Cassard
ResearchOpen Access01 May 2018
Scientific Reports

Volume: 8, P: 1-9
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Cindy N Roy
Ángel O Custodio
Martina U Muckenthaler
Research18 Apr 2004
Nature Genetics

Volume: 36, P: 481-485
Effects of intramuscularly injected plant-derived antimicrobials in the mouse model

Elizabeth J. Johnson
Jingyue Ellie Duan
Xiuchun Cindy Tian
ResearchOpen Access08 Apr 2022
Scientific Reports

Volume: 12, P: 1-9
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL complex and provide evidence that NSL-deposited histone acetylation induces BRD4 recruitment for transcription of constitutively active genes.

Aline Gaub
Bilal N. Sheikh
Asifa Akhtar
ResearchOpen Access07 May 2020
Nature Communications

Volume: 11, P: 1-17
Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy

Shintaro Akiyama
Joëlle St-Pierre
David T. Rubin
ResearchOpen Access02 Aug 2024
npj Gut and Liver

Volume: 1, P: 1-7
Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant

Ning Yang
Aitor Garcia
Liang Deng
ResearchOpen Access19 Oct 2022
npj Vaccines

Volume: 7, P: 1-15
Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model

Hung-Chih Chen
Yu-Che Cheng
Patrick C. H. Hsieh
ResearchOpen Access15 Jan 2025
npj Regenerative Medicine

Volume: 10, P: 1-11
Pharmacokinetics of tebipenem pivoxil used in children suffering from shigellosis: a pilot study in Bangladesh

Sharika Nuzhat
Md Ridwan Islam
Tahmeed Ahmed
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
Genome-wide haplotype association analysis of primary biliary cholangitis risk in Japanese

Cindy Im
Yadav Sapkota
Yutaka Yasui
ResearchOpen Access17 May 2018
Scientific Reports

Volume: 8, P: 1-11
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

Ninna Karsbæk Senftleber
Mette K. Andersen
Anders Albrechtsen
ResearchOpen Access30 Oct 2023
European Journal of Human Genetics

Volume: 32, P: 215-223
Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death

Matthew B Jarpe
Christian Widmann
Gary L Johnson
Reviews22 Sept 1998
Oncogene

Volume: 17, P: 1475-1482
Mentoring the future of neonatology: program director advice for fellowship applicants and their advisors

Morgan Hill
Brooke Vergales
Patrick Myers
Comments & Opinion20 Sept 2025
Journal of Perinatology

P: 1-3
Altered gene expression and PTSD symptom dimensions in World Trade Center responders

Shelby Marchese
Leo Cancelmo
Adriana Feder
Research17 Feb 2022
Molecular Psychiatry

Volume: 27, P: 2225-2246
Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors

Cindy Im
Kirsten K. Ness
Carmen L. Wilson
Research18 Jan 2018
European Journal of Human Genetics

Volume: 26, P: 275-286
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Lakis et al. report novel findings related to the epigenetic landscape of pancreatic neuroendocrine cancer. This relatively large cohort provides functional insights into the epigenetic wiring of pancreatic neuroendocrine tumor sub-types with the potential ability to stratify tumours of different prognosis.

Vanessa Lakis
Rita T. Lawlor
Aldo Scarpa
ResearchOpen Access03 Feb 2021
Communications Biology

Volume: 4, P: 1-11
Pilot dose-ranging of rhIGF-1/rhIGFBP-3 in a preterm lamb model of evolving bronchopulmonary dysplasia

Kurt H. Albertine
Mar Janna Dahl
Robert Ward
Research27 Aug 2022
Pediatric Research

Volume: 93, P: 1528-1538

Search

Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency

Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Molecular characterization of the Arabidopsis floral homeotic gene APETALA1

Treatment, toxicity, and mortality after subsequent breast cancer in female survivors of childhood cancer

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Cytotoxic T cells that escape exhaustion

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

INTRAVENTRICULAR HEMORRHAGE (IVH) & VITAMIN E (VE) IN VERY LOW BIRTH WEIGHT INFANTS: EFFICACY OF EARLY IM ADMINISTRATION

Systematic assessment of long-read RNA-seq methods for transcript identification and quantification

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Mapping the human genetic architecture of COVID-19

African bushpigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands

Late preterm antenatal steroid use and infant outcomes in a single center

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

Fatty acid transport protein 2 reprograms neutrophils in cancer

Transplantation of human microbiota into conventional mice durably reshapes the gut microbiota

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Effects of intramuscularly injected plant-derived antimicrobials in the mouse model

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy

Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant

Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model

Pharmacokinetics of tebipenem pivoxil used in children suffering from shigellosis: a pilot study in Bangladesh

Genome-wide haplotype association analysis of primary biliary cholangitis risk in Japanese

GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death

Mentoring the future of neonatology: program director advice for fellowship applicants and their advisors

Altered gene expression and PTSD symptom dimensions in World Trade Center responders

Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Pilot dose-ranging of rhIGF-1/rhIGFBP-3 in a preterm lamb model of evolving bronchopulmonary dysplasia

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