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Black and white fonio are two small indigenous grain cereals grown in West Africa. Here, the authors reveal their independent domestication and cultivation histories through population genetics and demographic history analyses.

In the first results from an ongoing global cancer screening data repository, screening program organization was better overall in Europe compared to other continents; however, there were substantial gaps in implementation across both high- and low-resource settings.

Antimicrobial resistance genes that have been mobilized between bacterial species represent a subset of the naturally occurring resistome. Here, the authors compare the abundance, diversity and geographical patterns of acquired resistance genes with latent resistance genes in global sewage metagenomes.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Avec le réchauffement de la planète, les organismes qui propagent les maladies tropicales négligées s'implantent en Europe. Les pays riches doivent se préparer à une augmentation du nombre de cas.

Marine Protected Areas (MPAs) management usually involves bringing multiple stakeholders together, to construct policy-relevant research programs and science-based tools for adaptive management. Here, we present the conclusions of a transdisciplinary workshop that aimed at reviewing experiences in the co-design of EBM research in MPAs. We find that MPAs represent powerful instruments for conducting real-world experiments, de facto acting as living labs in support of ocean governance.

Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

Superfluidity of light enables movement without friction or, in optical terms, diffraction. Here, Michel et al. report the detection of the transition to superfluidity in the flow of a fluid of light past an obstacle in a bulk nonlinear crystal and extract the drag force exerted by the fluid of light.

In patients with newly diagnosed, transplant-ineligible multiple myeloma, addition of weekly bortzomib to isatuximab, lenalidomide and dexamethasone leads to increased minimal residual disease negativity compared with isatuximab, lenalidomide and dexamethasone.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

How nicotine impacts the adolescent development of neural circuitry is not fully understood. Here authors show that early adolescent nicotine exposure in male mice blocked the maturation of nicotine-evoked dopamine signaling, causing an immature, vulnerable behavioral response in adult mice. Restoring their adult-like nicotine-evoked signaling unmasks a mature behavioral response in male mice.

Interpreting untargeted mass spectrometry (MS) data is challenging due to incomplete reference libraries. Here, the authors created the nearest neighbor suspect spectral library from largescale public MS data, significantly enhancing the ability to hypothesize structures for unknown mass spectra.

Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

Analysis of data from the COVID Symptom Study app reveals fatigue, headache, dyspnea and anosmia as key attributes of long COVID, with those experiencing five or more symptoms during the first week of being at increased risk of prolonged disease.

As low-carbon energy technologies advance, markets are driving demand for energy transition metals, increasing the stress placed on people and the environment in extractive locations. Here, the authors quantify this stress by developing a set of global composite environmental, social and governance risk indicators, and find that 84% of platinum resources and 70% of cobalt resources are located in high-risk contexts.

Drosophila mesoderm invagination begins with the formation of a furrow. Here they show that a long-range mechanism, powered by actomyosin contraction between the embryo polar caps, works like a ‘cheese-cutter wire’ indenting the tissue surface and folding it into a propagating furrow.

Disentangling causal interactions among biodiversity, ecosystem functioning and environmental factors is key to understanding how ecosystems respond to changing environment. This study presents a global scale analysis quantifying causal interactions and feedbacks among phytoplankton diversity, biomass and nutrients along environmental gradients of aquatic ecosystems.

MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

The InSight lander has expanded our knowledge of the atmosphere of Mars by observing various phenomena, including airglow, bores, infrasound and Earth-like turbulence.

Observations from the Lucy spacecraft of the small main-belt asteroid (152830) Dinkinesh reveals unexpected complexity, with a longitudinal trough and equatorial ridge, as well as the discovery of the first contact binary satellite.

Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn’s disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.

Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.

Marginal zone lymphoma (MZL) is a common subtype of B-cell non-Hodgkin lymphoma. Here the authors carry out a two-stage genome-wide association study in over 8,000 Europeans and identify two new MZL risk loci at chromosome 6p, implicating the major histocompatibility complex in the disease for the first time.

A model of how local relatedness changes with age fits empirical patterns from seven group-living mammal species and reveals that patterns differ between the sexes and the potential behavioural consequences of these changes.

Atoms in a semiconductor can have non-zero nuclear spins, creating a large ensemble with many quantum degrees of freedom. An electron spin coupled to the nuclei of a semiconductor quantum dot can witness the creation of entanglement within the ensemble.

Repeated exposure to social stressors in rodents results in behavioural changes. Here the authors show that behavioural adaptations to stress are associated with nuclear organization changes through SWI/SNF chromatin remodeler in specific neuronal populations of the mesolimbic system.

Although plant functional trait combinations reflect ecological trade-offs at the species level, little is known about how this translates to whole communities. Here, the authors show that global trait composition is captured by two main dimensions that are only weakly related to macro-environmental drivers.

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a non-Hodgkin-type B cell lymphoma. Here, the authors identify two risk loci for WM/LPL in a two-stage GWAS involving a family-oversampling approach and provide evidence for a functional role of the non-coding SNP rs116446171.

Susan Slager and colleagues report a meta-analysis of genome-wide association studies for chronic lymphocytic leukemia (CLL). They identify nine loci newly associated with CLL.

A phase transition between disordered and quasi-ordered states, known as the Berezinskii–Kosterlitz–Thouless transition, has now been revealed in a two-dimensional photonic ‘fluid’. The interplay between phase singularities and coherence may lead to new vortex-based optical applications.

Xavier Argout and colleagues report the draft genome of Theobroma cacao, the tropical crop that is the source of chocolate. The sequence assembly covers approximately 80% of the genome.