Nature Search

Homophily within and across groups

People tend to connect with similar others in different groups, shaping how ideas and diseases spread. The authors introduce a data-validated model that captures homophily across group sizes and show it can raise or lower connectivity and epidemic thresholds, informing better intervention design.

Abbas K. Rizi
Riccardo Michielan
Mikko Kivelä
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-12
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

Klein and colleagues characterize 04_A06, a new V_H1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain full viral suppression in HIV-1-infected humanized mice.

Lutz Gieselmann
Andrew T. DeLaitsch
Florian Klein
ResearchOpen Access06 Oct 2025
Nature Immunology

Volume: 26, P: 2016-2029
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Correction: Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Marina Caskey
Florian Klein
Michel C. Nussenzweig
Amendments and Corrections23 Mar 2016
Nature

Volume: 535, P: 580
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant

Neutralization of the SARS-CoV-2 Omicron variant is markedly impaired in sera from recipients of two doses of the COVID-19 vaccine BNT162b2 or from convalescent individuals, but is robustly increased in both groups following a booster vaccine dose.

Henning Gruell
Kanika Vanshylla
Florian Klein
ResearchOpen Access19 Jan 2022
Nature Medicine

Volume: 28, P: 477-480
Ondansetron to reduce neonatal opioid withdrawal severity a randomized clinical trial

Gary Peltz
Lauren M. Jansson
Walter K. Kraft
Research27 Aug 2022
Journal of Perinatology

Volume: 43, P: 271-276
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
The clinical relevance of ultra-widefield angiography findings in patients with central retinal vein occlusion and macular oedema receiving anti-VEGF therapy

Luke Nicholson
Clara Vazquez-Alfageme
Philip G. Hykin
ResearchOpen Access25 May 2021
Eye

Volume: 36, P: 1086-1093
Swarm Learning for decentralized and confidential clinical machine learning

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Stefanie Warnat-Herresthal
Hartmut Schultze
Joachim L. Schultze
ResearchOpen Access26 May 2021
Nature

Volume: 594, P: 265-270
Dynamics and durability of HIV-1 neutralization are determined by viral replication

Human immunodeficiency virus type 1 (HIV-1)-neutralizing responses can persist for several years, even at low antigen levels, suggesting that an HIV-1 vaccine may be able to elicit a durable antibody response.

Philipp Schommers
Dae Sung Kim
Florian Klein
ResearchOpen Access13 Nov 2023
Nature Medicine

Volume: 29, P: 2763-2774
Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Pilar Mendoza
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature

Volume: 561, P: 479-484
ARID2-related disorder: further delineation of the clinical phenotype of 27 novel individuals and description of an epigenetic signature

Clara Houdayer
Kathleen Rooney
Estelle Colin
ResearchOpen Access05 Mar 2025
European Journal of Human Genetics

Volume: 33, P: 1422-1431
Arctic mercury flux increased through the Last Glacial Termination with a warming climate

Mercury deposition onto the Greenland Ice Sheet increased from the Last Glacial Termination to early Holocene as the North Atlantic warmed and sea ice retreated, according to an ice-core mercury record and atmospheric chemistry modelling.

Delia Segato
Alfonso Saiz-Lopez
Andrea Spolaor
Research04 May 2023
Nature Geoscience

Volume: 16, P: 439-445
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in blood, but antibody-resistant virus did emerge.

Marina Caskey
Till Schoofs
Florian Klein
Research16 Jan 2017
Nature Medicine

Volume: 23, P: 185-191
Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infection

Functional T cell exhaustion occurs during chronic viral infection or in tumor settings. Beyer et al. report that chronic inflammation mediated by the cytokine TNF is responsible for this dysfunction and that blockade of this pathway restores immune system–mediated control of viral infection.

Marc Beyer
Zeinab Abdullah
Joachim L Schultze
Research07 Mar 2016
Nature Immunology

Volume: 17, P: 593-603
Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infection

Marc Beyer
Zeinab Abdullah
Joachim L. Schultze
Amendments and Corrections03 Jul 2020
Nature Immunology

Volume: 21, P: 1135
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

Ding and colleagues use bulk, single-cell and single-nucleus multi-omics together with spatial transcriptomics and multiplex imaging of clinical tumor samples to characterize gene expression and chromatin accessibility of breast cancer lineages.

Michael D. Iglesia
Reyka G. Jayasinghe
Li Ding
ResearchOpen Access30 Oct 2024
Nature Cancer

Volume: 5, P: 1713-1736
The relationship between neurological level of injury and symptomatic cardiovascular disease risk in the aging spinal injured

SL Groah
D Weitzenkamp
G Savic
Research06 Jul 2001
Spinal Cord

Volume: 39, P: 310-317
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition

Julia Fischer
Lisa Rusyn
Tamina Seeger-Nukpezah
ResearchOpen Access12 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-13
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

A phase I study of passive immunization with a CD4 binding-site-directed broadly neutralizing antibody shows that it transiently reduces HIV-1 viral loads in humans.

Marina Caskey
Florian Klein
Michel C. Nussenzweig
Research08 Apr 2015
Nature

Volume: 522, P: 487-491
Correction: Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition

Julia Fischer
Lisa Rusyn
Tamina Seeger-Nukpezah
Amendments and CorrectionsOpen Access29 Aug 2025
Cell Death & Disease

Volume: 16, P: 1
A gravitational-wave standard siren measurement of the Hubble constant

The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

B. P. Abbott
R. Abbott
M. Serra-Ricart
Research16 Oct 2017
Nature

Volume: 551, P: 85-88
Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

Jens Peter Klussmann
Maria Grosheva
Ralph Mösges
ResearchOpen Access26 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells

Roland Lehmann
Mario M Müller
Hortense Slevogt
Research03 Jan 2018
Mucosal Immunology

Volume: 11, P: 627-642
Activation of distinct inflammatory pathways in subgroups of LR-MDS

Marie Schneider
Clara Rolfs
Uwe Platzbecker
ResearchOpen Access07 Jul 2023
Leukemia

Volume: 37, P: 1709-1718
Molecular Epidemiology of the HIV Epidemic in Three German Metropolitan Regions – Cologne/Bonn, Munich and Hannover, 1999–2016

Melanie Stecher
Antoine Chaillon
Martin Hoenigl
ResearchOpen Access01 May 2018
Scientific Reports

Volume: 8, P: 1-9
Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

CD98hc in macrophages attenuates the severity of colitis. This change in the macrophage development is associated with increased expression of apoptotic genes, suggesting that CD98hc maintains the gut homeostasis by ensuring the development of gut macrophages.

Philipp Wuggenig
Berna Kaya
Jan Hendrik Niess
ResearchOpen Access18 Mar 2020
Communications Biology

Volume: 3, P: 1-19

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