Nature Search

Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy

The clinical translation of STING agonists is limited by suboptimal response rates and dose-limiting toxicities. Here, this group identifies a regulator of cholesterol metabolism as a negative modulator of STING activation, then develops a formulation delivering low-dose STING agonist alongside PCSK9-targeting siRNA for cancer therapy.

Pengbo Sun
Fangping Han
Rui Kuai
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity

Chemotherapy-induced cytosolic DNA has been shown to activate the cGAS-STING pathway. Here, the authors demonstrate that the efficacy of low-dose doxorubicin to elicit a STING-mediated anti-tumour immune response can be enhanced by liposomal-loading with indocyanine green, resulting in ultrasound-activatable enhanced nuclear doxorubicin localisation and release of mitochondrial DNA.

Chaoyu Wang
Ruoshi Zhang
Rui Kuai
ResearchOpen Access30 Jun 2023
Nature Communications

Volume: 14, P: 1-16
Structural basis of STING binding with and phosphorylation by TBK1

The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires oligomerization of both proteins.

Conggang Zhang
Guijun Shang
Zhijian J. Chen
Research06 Mar 2019
Nature

Volume: 567, P: 394-398
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Cryo-electron microscopy structures of full-length STING show that cyclic GMP–AMP induces a half-turn rotation of the ligand-binding domain relative to the transmembrane domain, forming a tetramer and higher-order oligomers for signalling.

Guijun Shang
Conggang Zhang
Xuewu Zhang
Research06 Mar 2019
Nature

Volume: 567, P: 389-393
A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional histidine kinases.

Yixiang Liu
Joshua Rose
Ling Jiang
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-10
Regulation of cGAS–STING signalling and its diversity of cellular outcomes

This Review summarizes mechanisms for the regulation of cGAS–STING signalling, describes its crosstalk with other signalling pathways, and outlines the diverse cellular outcomes of cGAS–STING biology and its roles in inflammatory disease, ageing and tumorigenesis.

Zhengyin Zhang
Conggang Zhang
Reviews07 Jan 2025
Nature Reviews Immunology

Volume: 25, P: 425-444
C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone

C-terminal truncation of a-syn results in a more extended and exposed conformation, providing further insight into the pathological role of this truncation event in the progression of Parkinson’s disease.

Cai Zhang
Yunshan Pei
Conggang Li
ResearchOpen Access09 Aug 2022
Communications Biology

Volume: 5, P: 1-10
A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

Conggang Zhang
Schuyler Lee
Xuedong Liu
Correspondence05 Dec 2014
Cell Research

Volume: 25, P: 394-397

Search

Filter By:

Search

Quick links